Cargando…
Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution
This study aimed to investigate the accuracy and safety of fine-needle aspiration cytology (FNAC) in Chinese patients with acral and cutaneous melanoma, and also to evaluate the influencing factors and their impact on prognosis. Data of 128 patients with stage 0–III acral and cutaneous melanoma trea...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604510/ https://www.ncbi.nlm.nih.gov/pubmed/33194572 http://dx.doi.org/10.3389/fonc.2020.01724 |
_version_ | 1783604155655389184 |
---|---|
author | Yang, Lingge Sun, Wei Xu, Yu Zhang, Xun Wang, Shengping Wang, Chunmeng Chen, Yong |
author_facet | Yang, Lingge Sun, Wei Xu, Yu Zhang, Xun Wang, Shengping Wang, Chunmeng Chen, Yong |
author_sort | Yang, Lingge |
collection | PubMed |
description | This study aimed to investigate the accuracy and safety of fine-needle aspiration cytology (FNAC) in Chinese patients with acral and cutaneous melanoma, and also to evaluate the influencing factors and their impact on prognosis. Data of 128 patients with stage 0–III acral and cutaneous melanoma treated in Fudan University Shanghai Cancer Center from 2009 to 2016 were collected from a prospective database. Further, 128 patients who did not undergo FNAC but had similar parameters were recruited as the matched group. Clinical features, FNAC status, and recurrence or metastasis status of patients were analyzed for overall survival (OS), melanoma-specific survival (MSS), recurrence-free survival (RFS), and metastasis-free survival (MFS). Of the 128 patients with FNAC, 5.5% (7/128) had a negative cytological diagnosis, 12.2% (5/41) had primary lesions, and 2.3% (2/87) had lesions in lymph nodes. Tumor thickness, status of ulceration, and subtype were not associated with accuracy for both primary and lymph node FNAC. With a median follow-up of 40 months in all patients, 55 had melanoma-specific death; the median OS and MSS were 95 months and 104 months, respectively. Patients with FNAC had significantly worse OS. Tumor progression occurred in 130 patients. The survival analysis revealed differences in OS and disease-free survival between the two groups. FNAC impacted patients' RFS and MFS; the difference in survival curves of RFS and MFS was also statistically significant. FNAC on primary or superficial lymphatic lesions was a good diagnostic tool for Chinese patients with acral and cutaneous melanoma, but it adversely impacted prognosis. |
format | Online Article Text |
id | pubmed-7604510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76045102020-11-13 Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution Yang, Lingge Sun, Wei Xu, Yu Zhang, Xun Wang, Shengping Wang, Chunmeng Chen, Yong Front Oncol Oncology This study aimed to investigate the accuracy and safety of fine-needle aspiration cytology (FNAC) in Chinese patients with acral and cutaneous melanoma, and also to evaluate the influencing factors and their impact on prognosis. Data of 128 patients with stage 0–III acral and cutaneous melanoma treated in Fudan University Shanghai Cancer Center from 2009 to 2016 were collected from a prospective database. Further, 128 patients who did not undergo FNAC but had similar parameters were recruited as the matched group. Clinical features, FNAC status, and recurrence or metastasis status of patients were analyzed for overall survival (OS), melanoma-specific survival (MSS), recurrence-free survival (RFS), and metastasis-free survival (MFS). Of the 128 patients with FNAC, 5.5% (7/128) had a negative cytological diagnosis, 12.2% (5/41) had primary lesions, and 2.3% (2/87) had lesions in lymph nodes. Tumor thickness, status of ulceration, and subtype were not associated with accuracy for both primary and lymph node FNAC. With a median follow-up of 40 months in all patients, 55 had melanoma-specific death; the median OS and MSS were 95 months and 104 months, respectively. Patients with FNAC had significantly worse OS. Tumor progression occurred in 130 patients. The survival analysis revealed differences in OS and disease-free survival between the two groups. FNAC impacted patients' RFS and MFS; the difference in survival curves of RFS and MFS was also statistically significant. FNAC on primary or superficial lymphatic lesions was a good diagnostic tool for Chinese patients with acral and cutaneous melanoma, but it adversely impacted prognosis. Frontiers Media S.A. 2020-10-19 /pmc/articles/PMC7604510/ /pubmed/33194572 http://dx.doi.org/10.3389/fonc.2020.01724 Text en Copyright © 2020 Yang, Sun, Xu, Zhang, Wang, Wang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Yang, Lingge Sun, Wei Xu, Yu Zhang, Xun Wang, Shengping Wang, Chunmeng Chen, Yong Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution |
title | Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution |
title_full | Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution |
title_fullStr | Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution |
title_full_unstemmed | Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution |
title_short | Fine Needle Aspiration Cytology (FNAC) for Chinese Patients With Acral and Cutaneous Melanoma: Accuracy and Safety Analysis From a Single Institution |
title_sort | fine needle aspiration cytology (fnac) for chinese patients with acral and cutaneous melanoma: accuracy and safety analysis from a single institution |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604510/ https://www.ncbi.nlm.nih.gov/pubmed/33194572 http://dx.doi.org/10.3389/fonc.2020.01724 |
work_keys_str_mv | AT yanglingge fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution AT sunwei fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution AT xuyu fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution AT zhangxun fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution AT wangshengping fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution AT wangchunmeng fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution AT chenyong fineneedleaspirationcytologyfnacforchinesepatientswithacralandcutaneousmelanomaaccuracyandsafetyanalysisfromasingleinstitution |