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β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons

In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of adult‐born neurons. We investigated the role of canonical Wn...

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Autores principales: Heppt, Jana, Wittmann, Marie‐Theres, Schäffner, Iris, Billmann, Charlotte, Zhang, Jingzhong, Vogt‐Weisenhorn, Daniela, Prakash, Nilima, Wurst, Wolfgang, Taketo, Makoto Mark, Lie, Dieter Chichung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604596/
https://www.ncbi.nlm.nih.gov/pubmed/32929771
http://dx.doi.org/10.15252/embj.2020104472
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author Heppt, Jana
Wittmann, Marie‐Theres
Schäffner, Iris
Billmann, Charlotte
Zhang, Jingzhong
Vogt‐Weisenhorn, Daniela
Prakash, Nilima
Wurst, Wolfgang
Taketo, Makoto Mark
Lie, Dieter Chichung
author_facet Heppt, Jana
Wittmann, Marie‐Theres
Schäffner, Iris
Billmann, Charlotte
Zhang, Jingzhong
Vogt‐Weisenhorn, Daniela
Prakash, Nilima
Wurst, Wolfgang
Taketo, Makoto Mark
Lie, Dieter Chichung
author_sort Heppt, Jana
collection PubMed
description In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of adult‐born neurons. We investigated the role of canonical Wnt/β‐catenin signaling in dendritogenesis of adult‐born neurons. We show that canonical Wnt signaling follows a biphasic pattern, with high activity in stem/progenitor cells, attenuation in immature neurons, and reactivation during maturation, and demonstrate that this activity pattern is required for proper dendrite development. Increasing β‐catenin signaling in maturing neurons of young adult mice transiently accelerated dendritic growth, but eventually produced dendritic defects and excessive spine numbers. In middle‐aged mice, in which protracted dendrite and spine development were paralleled by lower canonical Wnt signaling activity, enhancement of β‐catenin signaling restored dendritic growth and spine formation to levels observed in young adult animals. Our data indicate that precise timing and strength of β‐catenin signaling are essential for the correct functional integration of adult‐born neurons and suggest Wnt/β‐catenin signaling as a pathway to ameliorate deficits in adult neurogenesis during aging.
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spelling pubmed-76045962020-11-05 β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons Heppt, Jana Wittmann, Marie‐Theres Schäffner, Iris Billmann, Charlotte Zhang, Jingzhong Vogt‐Weisenhorn, Daniela Prakash, Nilima Wurst, Wolfgang Taketo, Makoto Mark Lie, Dieter Chichung EMBO J Articles In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of adult‐born neurons. We investigated the role of canonical Wnt/β‐catenin signaling in dendritogenesis of adult‐born neurons. We show that canonical Wnt signaling follows a biphasic pattern, with high activity in stem/progenitor cells, attenuation in immature neurons, and reactivation during maturation, and demonstrate that this activity pattern is required for proper dendrite development. Increasing β‐catenin signaling in maturing neurons of young adult mice transiently accelerated dendritic growth, but eventually produced dendritic defects and excessive spine numbers. In middle‐aged mice, in which protracted dendrite and spine development were paralleled by lower canonical Wnt signaling activity, enhancement of β‐catenin signaling restored dendritic growth and spine formation to levels observed in young adult animals. Our data indicate that precise timing and strength of β‐catenin signaling are essential for the correct functional integration of adult‐born neurons and suggest Wnt/β‐catenin signaling as a pathway to ameliorate deficits in adult neurogenesis during aging. John Wiley and Sons Inc. 2020-09-15 2020-11-02 /pmc/articles/PMC7604596/ /pubmed/32929771 http://dx.doi.org/10.15252/embj.2020104472 Text en © 2020 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Heppt, Jana
Wittmann, Marie‐Theres
Schäffner, Iris
Billmann, Charlotte
Zhang, Jingzhong
Vogt‐Weisenhorn, Daniela
Prakash, Nilima
Wurst, Wolfgang
Taketo, Makoto Mark
Lie, Dieter Chichung
β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
title β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
title_full β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
title_fullStr β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
title_full_unstemmed β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
title_short β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
title_sort β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604596/
https://www.ncbi.nlm.nih.gov/pubmed/32929771
http://dx.doi.org/10.15252/embj.2020104472
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