Novel aptamer to von Willebrand factor A1 domain (TAGX-0004) shows total inhibition of thrombus formation superior to ARC1779 and comparable to caplacizumab

Von Willebrand factor (VWF) is a blood glycoprotein that plays an important role in platelet thrombus formation through interaction between its A1 domain and platelet glycoprotein Ib. ARC1779, an aptamer to the VWF A1 domain, was evaluated in a clinical trial for acquired thrombotic thrombocytopenic...

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Detalles Bibliográficos
Autores principales: Sakai, Kazuya, Someya, Tatsuhiko, Harada, Kaori, Yagi, Hideo, Matsui, Taei, Matsumoto, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604614/
https://www.ncbi.nlm.nih.gov/pubmed/33131252
http://dx.doi.org/10.3324/haematol.2019.235549

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