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Sensitive manipulation of CAR T cell activity using a chimeric endocytosing receptor

BACKGROUND: Most adoptive cell therapies (ACTs) suffer from an inability to control the therapeutic cell’s behavior following its transplantation into a patient. Thus, efforts to inhibit, activate, differentiate or terminate an ACT after patient reinfusion can be futile, because the required drug ad...

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Detalles Bibliográficos
Autores principales:	Zhang, Boning, Napoleon, John Victor, Liu, Xin, Luo, Qian, Srinivasarao, Madduri, Low, Philip S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604868/ https://www.ncbi.nlm.nih.gov/pubmed/33127654 http://dx.doi.org/10.1136/jitc-2020-000756

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