Cargando…

Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity

One of the approaches used to eliminate tumor cells is directed destruction/modification of their RNA molecules. In this regard, ribonucleases (RNases) possess a therapeutic potential that remains largely unexplored. It is believed that the biological effects of secreted RNases, namely their antitum...

Descripción completa

Detalles Bibliográficos
Autores principales: Dudkina, E. V., Ulyanova, V. V., Ilinskaya, O. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604891/
https://www.ncbi.nlm.nih.gov/pubmed/33173594
http://dx.doi.org/10.32607/actanaturae.11000
_version_ 1783604210271518720
author Dudkina, E. V.
Ulyanova, V. V.
Ilinskaya, O. N.
author_facet Dudkina, E. V.
Ulyanova, V. V.
Ilinskaya, O. N.
author_sort Dudkina, E. V.
collection PubMed
description One of the approaches used to eliminate tumor cells is directed destruction/modification of their RNA molecules. In this regard, ribonucleases (RNases) possess a therapeutic potential that remains largely unexplored. It is believed that the biological effects of secreted RNases, namely their antitumor and antiviral properties, derive from their catalytic activity. However, a number of recent studies have challenged the notion that the activity of RNases in the manifestation of selective cytotoxicity towards cancer cells is exclusively an enzymatic one. In this review, we have analyzed available data on the cytotoxic effects of secreted RNases, which are not associated with their catalytic activity, and we have provided evidence that the most important factor in the selective apoptosis-inducing action of RNases is the structural organization of these enzymes, which determines how they interact with cell components. The new idea on the preponderant role of non-catalytic interactions between RNases and cancer cells in the manifestation of selective cytotoxicity will contribute to the development of antitumor RNase-based drugs.
format Online
Article
Text
id pubmed-7604891
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher A.I. Gordeyev
record_format MEDLINE/PubMed
spelling pubmed-76048912020-11-09 Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity Dudkina, E. V. Ulyanova, V. V. Ilinskaya, O. N. Acta Naturae Research Article One of the approaches used to eliminate tumor cells is directed destruction/modification of their RNA molecules. In this regard, ribonucleases (RNases) possess a therapeutic potential that remains largely unexplored. It is believed that the biological effects of secreted RNases, namely their antitumor and antiviral properties, derive from their catalytic activity. However, a number of recent studies have challenged the notion that the activity of RNases in the manifestation of selective cytotoxicity towards cancer cells is exclusively an enzymatic one. In this review, we have analyzed available data on the cytotoxic effects of secreted RNases, which are not associated with their catalytic activity, and we have provided evidence that the most important factor in the selective apoptosis-inducing action of RNases is the structural organization of these enzymes, which determines how they interact with cell components. The new idea on the preponderant role of non-catalytic interactions between RNases and cancer cells in the manifestation of selective cytotoxicity will contribute to the development of antitumor RNase-based drugs. A.I. Gordeyev 2020 /pmc/articles/PMC7604891/ /pubmed/33173594 http://dx.doi.org/10.32607/actanaturae.11000 Text en Copyright ® 2020 National Research University Higher School of Economics. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dudkina, E. V.
Ulyanova, V. V.
Ilinskaya, O. N.
Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity
title Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity
title_full Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity
title_fullStr Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity
title_full_unstemmed Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity
title_short Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity
title_sort supramolecular organization as a factor of ribonuclease cytotoxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604891/
https://www.ncbi.nlm.nih.gov/pubmed/33173594
http://dx.doi.org/10.32607/actanaturae.11000
work_keys_str_mv AT dudkinaev supramolecularorganizationasafactorofribonucleasecytotoxicity
AT ulyanovavv supramolecularorganizationasafactorofribonucleasecytotoxicity
AT ilinskayaon supramolecularorganizationasafactorofribonucleasecytotoxicity