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Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma
OBJECTIVE: This study aimed to explore the use of different combinations of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) for the early diagnosis of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-associated l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604992/ https://www.ncbi.nlm.nih.gov/pubmed/31852373 http://dx.doi.org/10.1177/0300060519889270 |
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author | Song, Ting Wang, Lili Su, Bin Zeng, Weiping Jiang, Taiyi Zhang, Tong Sun, Guizhen Wu, Hao |
author_facet | Song, Ting Wang, Lili Su, Bin Zeng, Weiping Jiang, Taiyi Zhang, Tong Sun, Guizhen Wu, Hao |
author_sort | Song, Ting |
collection | PubMed |
description | OBJECTIVE: This study aimed to explore the use of different combinations of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) for the early diagnosis of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-associated liver cirrhosis (LC). METHODS: There were 167 subjects, including 100 with HCC and 67 with LC, who were enrolled into this study. Serum AFP, AFP-L3, and DCP levels were detected by chemiluminescent enzyme immunoassay and analyzed using the receiver operating characteristics (ROC) method. RESULTS: The sensitivity and specificity of AFP and DCP for differentiating between early HCC and HBV-associated LC were 51.5% and 92.5%, and 60.0% and 84.7%, respectively. Comparative analysis of ROC curves showed no significant difference in the area under the curve (AUC) for AFP and DCP. Moreover, the combination of AFP and DCP showed the largest AUC value with a diagnostic sensitivity and specificity of 67% and 83.1%, respectively. CONCLUSION: These results suggest that AFP is the best single biomarker for distinguishing between HBV-associated LC and early HCC induced by HBV. However, the combination of AFP and DCP can enhance the diagnostic value of AFP for differentiating between these diseases. |
format | Online Article Text |
id | pubmed-7604992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-76049922020-11-12 Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma Song, Ting Wang, Lili Su, Bin Zeng, Weiping Jiang, Taiyi Zhang, Tong Sun, Guizhen Wu, Hao J Int Med Res Pre-Clinical Research Report OBJECTIVE: This study aimed to explore the use of different combinations of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) for the early diagnosis of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-associated liver cirrhosis (LC). METHODS: There were 167 subjects, including 100 with HCC and 67 with LC, who were enrolled into this study. Serum AFP, AFP-L3, and DCP levels were detected by chemiluminescent enzyme immunoassay and analyzed using the receiver operating characteristics (ROC) method. RESULTS: The sensitivity and specificity of AFP and DCP for differentiating between early HCC and HBV-associated LC were 51.5% and 92.5%, and 60.0% and 84.7%, respectively. Comparative analysis of ROC curves showed no significant difference in the area under the curve (AUC) for AFP and DCP. Moreover, the combination of AFP and DCP showed the largest AUC value with a diagnostic sensitivity and specificity of 67% and 83.1%, respectively. CONCLUSION: These results suggest that AFP is the best single biomarker for distinguishing between HBV-associated LC and early HCC induced by HBV. However, the combination of AFP and DCP can enhance the diagnostic value of AFP for differentiating between these diseases. SAGE Publications 2019-12-18 /pmc/articles/PMC7604992/ /pubmed/31852373 http://dx.doi.org/10.1177/0300060519889270 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Pre-Clinical Research Report Song, Ting Wang, Lili Su, Bin Zeng, Weiping Jiang, Taiyi Zhang, Tong Sun, Guizhen Wu, Hao Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma |
title | Diagnostic value of alpha-fetoprotein, Lens
culinaris agglutinin-reactive alpha-fetoprotein, and
des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular
carcinoma |
title_full | Diagnostic value of alpha-fetoprotein, Lens
culinaris agglutinin-reactive alpha-fetoprotein, and
des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular
carcinoma |
title_fullStr | Diagnostic value of alpha-fetoprotein, Lens
culinaris agglutinin-reactive alpha-fetoprotein, and
des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular
carcinoma |
title_full_unstemmed | Diagnostic value of alpha-fetoprotein, Lens
culinaris agglutinin-reactive alpha-fetoprotein, and
des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular
carcinoma |
title_short | Diagnostic value of alpha-fetoprotein, Lens
culinaris agglutinin-reactive alpha-fetoprotein, and
des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular
carcinoma |
title_sort | diagnostic value of alpha-fetoprotein, lens
culinaris agglutinin-reactive alpha-fetoprotein, and
des-gamma-carboxyprothrombin in hepatitis b virus-related hepatocellular
carcinoma |
topic | Pre-Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604992/ https://www.ncbi.nlm.nih.gov/pubmed/31852373 http://dx.doi.org/10.1177/0300060519889270 |
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