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Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems

BACKGROUND/AIM: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off...

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Autores principales: TURGUT, Didem, PİŞKİNPAŞA, Serhan Vahit, COŞKUN YENİGÜN, Ezgi, AYDEMİR, Nihal, DEDE, Fatih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605094/
https://www.ncbi.nlm.nih.gov/pubmed/32927927
http://dx.doi.org/10.3906/sag-2002-130
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author TURGUT, Didem
PİŞKİNPAŞA, Serhan Vahit
COŞKUN YENİGÜN, Ezgi
AYDEMİR, Nihal
DEDE, Fatih
author_facet TURGUT, Didem
PİŞKİNPAŞA, Serhan Vahit
COŞKUN YENİGÜN, Ezgi
AYDEMİR, Nihal
DEDE, Fatih
author_sort TURGUT, Didem
collection PubMed
description BACKGROUND/AIM: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. MATERIALS AND METHODS: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was carried out by measuring serum creatinine (sCr) and uNGAL at the time of diagnosis [0th min (T0)]. We followed the study group for three months. RESULTS: At the time of diagnosis, sCr (T0) was highest in the postrenal AKI and AKI groups in contrast to stable chronic kidney disease patients and healthy subjects (P < 0.001), as expected. T0 median uNGAL was highest in the postrenal group (P < 0.001). Area under curve (AUC) of uNGAL to estimate postrenal AKI presence was 0.957 (95% CI, 0.897–1.000; P < 0.001). The cut-off point of uNGAL was 42.625 ng/mL for this estimation. CONCLUSION: Patients with AKI must be classified according to the underlying etiologies as soon as possible. uNGAL may be useful to estimate the etiologies, and whether the problem is acute or chronic in the course. In postrenal kidney problems, to plan the urgency of the urologic procedures, it is crucial.
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spelling pubmed-76050942020-11-03 Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems TURGUT, Didem PİŞKİNPAŞA, Serhan Vahit COŞKUN YENİGÜN, Ezgi AYDEMİR, Nihal DEDE, Fatih Turk J Med Sci Article BACKGROUND/AIM: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. MATERIALS AND METHODS: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was carried out by measuring serum creatinine (sCr) and uNGAL at the time of diagnosis [0th min (T0)]. We followed the study group for three months. RESULTS: At the time of diagnosis, sCr (T0) was highest in the postrenal AKI and AKI groups in contrast to stable chronic kidney disease patients and healthy subjects (P < 0.001), as expected. T0 median uNGAL was highest in the postrenal group (P < 0.001). Area under curve (AUC) of uNGAL to estimate postrenal AKI presence was 0.957 (95% CI, 0.897–1.000; P < 0.001). The cut-off point of uNGAL was 42.625 ng/mL for this estimation. CONCLUSION: Patients with AKI must be classified according to the underlying etiologies as soon as possible. uNGAL may be useful to estimate the etiologies, and whether the problem is acute or chronic in the course. In postrenal kidney problems, to plan the urgency of the urologic procedures, it is crucial. The Scientific and Technological Research Council of Turkey 2020-10-22 /pmc/articles/PMC7605094/ /pubmed/32927927 http://dx.doi.org/10.3906/sag-2002-130 Text en Copyright © 2020 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
TURGUT, Didem
PİŞKİNPAŞA, Serhan Vahit
COŞKUN YENİGÜN, Ezgi
AYDEMİR, Nihal
DEDE, Fatih
Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
title Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
title_full Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
title_fullStr Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
title_full_unstemmed Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
title_short Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
title_sort urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605094/
https://www.ncbi.nlm.nih.gov/pubmed/32927927
http://dx.doi.org/10.3906/sag-2002-130
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