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The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation
Elevated levels of branched-chain amino acids (BCAAs) and their metabolites are strongly positively associated with obesity, insulin resistance, and type 2 diabetes. Bariatric surgery is among the best treatments for weight loss and associated morbidities. Clinical studies have reported that bariatr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605275/ https://www.ncbi.nlm.nih.gov/pubmed/33053352 http://dx.doi.org/10.1016/j.celrep.2020.108239 |
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author | Kramer, Nadejda Bozadjieva Evers, Simon S. Shin, Jae Hoon Silverwood, Sierra Wang, Yibin Burant, Charles F. Sandoval, Darleen A. Seeley, Randy J. |
author_facet | Kramer, Nadejda Bozadjieva Evers, Simon S. Shin, Jae Hoon Silverwood, Sierra Wang, Yibin Burant, Charles F. Sandoval, Darleen A. Seeley, Randy J. |
author_sort | Kramer, Nadejda Bozadjieva |
collection | PubMed |
description | Elevated levels of branched-chain amino acids (BCAAs) and their metabolites are strongly positively associated with obesity, insulin resistance, and type 2 diabetes. Bariatric surgery is among the best treatments for weight loss and associated morbidities. Clinical studies have reported that bariatric surgery decreases the circulating levels of BCAAs. The objective of this study was to test the hypothesis that reduced BCAA levels contribute to the metabolic improvements of sustained weight loss and improved glucose tolerance after vertical sleeve gastrectomy (VSG). We find that, as in humans, circulating BCAAs are significantly lower in VSG rats and mice. To increase circulating BCAAs, we tested mice with either increased dietary intake of BCAAs or impaired BCAA catabolism by total body deletion of mitochondrial phosphatase 2C (Pp2cm). Our results show that a decrease in circulating BCAAs is not necessary for sustained body weight loss and improved glucose tolerance after VSG. |
format | Online Article Text |
id | pubmed-7605275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-76052752020-11-02 The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation Kramer, Nadejda Bozadjieva Evers, Simon S. Shin, Jae Hoon Silverwood, Sierra Wang, Yibin Burant, Charles F. Sandoval, Darleen A. Seeley, Randy J. Cell Rep Article Elevated levels of branched-chain amino acids (BCAAs) and their metabolites are strongly positively associated with obesity, insulin resistance, and type 2 diabetes. Bariatric surgery is among the best treatments for weight loss and associated morbidities. Clinical studies have reported that bariatric surgery decreases the circulating levels of BCAAs. The objective of this study was to test the hypothesis that reduced BCAA levels contribute to the metabolic improvements of sustained weight loss and improved glucose tolerance after vertical sleeve gastrectomy (VSG). We find that, as in humans, circulating BCAAs are significantly lower in VSG rats and mice. To increase circulating BCAAs, we tested mice with either increased dietary intake of BCAAs or impaired BCAA catabolism by total body deletion of mitochondrial phosphatase 2C (Pp2cm). Our results show that a decrease in circulating BCAAs is not necessary for sustained body weight loss and improved glucose tolerance after VSG. 2020-10-13 /pmc/articles/PMC7605275/ /pubmed/33053352 http://dx.doi.org/10.1016/j.celrep.2020.108239 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kramer, Nadejda Bozadjieva Evers, Simon S. Shin, Jae Hoon Silverwood, Sierra Wang, Yibin Burant, Charles F. Sandoval, Darleen A. Seeley, Randy J. The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation |
title | The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation |
title_full | The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation |
title_fullStr | The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation |
title_full_unstemmed | The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation |
title_short | The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation |
title_sort | role of elevated branched-chain amino acids in the effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605275/ https://www.ncbi.nlm.nih.gov/pubmed/33053352 http://dx.doi.org/10.1016/j.celrep.2020.108239 |
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