The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is unclear to what extent melanomas rely on NRF2. Here we show t...

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Detalles Bibliográficos
Autores principales: Jessen, Christina, Kreß, Julia K. C., Baluapuri, Apoorva, Hufnagel, Anita, Schmitz, Werner, Kneitz, Susanne, Roth, Sabine, Marquardt, André, Appenzeller, Silke, Ade, Carsten P., Glutsch, Valerie, Wobser, Marion, Friedmann-Angeli, José Pedro, Mosteo, Laura, Goding, Colin R., Schilling, Bastian, Geissinger, Eva, Wolf, Elmar, Meierjohann, Svenja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605435/
https://www.ncbi.nlm.nih.gov/pubmed/32978520
http://dx.doi.org/10.1038/s41388-020-01477-8

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