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A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies

World Health Organisation declared COVID-19 a pandemic on March 11, 2020. It was temporarily named as 2019-nCoV then subsequently named as COVID-19 virus. A coronavirus is a group of viruses, known to be zoonotic, causing illness ranging from acute to mild respiratory infections. These are spherical...

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Autores principales: Rana, Rashmi, Rathi, Vaishnavi, Ganguly, Nirmal Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605460/
https://www.ncbi.nlm.nih.gov/pubmed/33162722
http://dx.doi.org/10.1007/s42485-020-00052-9
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author Rana, Rashmi
Rathi, Vaishnavi
Ganguly, Nirmal Kumar
author_facet Rana, Rashmi
Rathi, Vaishnavi
Ganguly, Nirmal Kumar
author_sort Rana, Rashmi
collection PubMed
description World Health Organisation declared COVID-19 a pandemic on March 11, 2020. It was temporarily named as 2019-nCoV then subsequently named as COVID-19 virus. A coronavirus is a group of viruses, known to be zoonotic, causing illness ranging from acute to mild respiratory infections. These are spherical or pleomorphic enveloped particles containing positive sense RNA. The virus enters host cells, its uncoated genetic material transcribes, and translates. Since it has started spreading rapidly, protective measures have been taken all over the world. However, its transmission has been proved to be unstoppable and the absence of an effective drug makes the situation worse. The scientific community has gone all-out to discover and develop a possible vaccine or a competent antiviral drug. Other domains of biological sciences that promise effective results and target somewhat stable entities that are proteins, could be very useful in this time of crisis. Proteomics and metabolomics are the vast fields that are equipped with sufficient technologies to face this challenge. Various protein separation and identification techniques are available which facilitates the analysis of various types of interactions among proteins and their evolutionary lineages. The presented review aims at confronting the question: ‘how proteomics can help in tackling SARS-CoV-2?’ It deals with the role of upcoming proteome technology in these pandemic situations and discusses the proteomics approach towards the COVID-19 dilemma.
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spelling pubmed-76054602020-11-03 A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies Rana, Rashmi Rathi, Vaishnavi Ganguly, Nirmal Kumar J Proteins Proteom Review World Health Organisation declared COVID-19 a pandemic on March 11, 2020. It was temporarily named as 2019-nCoV then subsequently named as COVID-19 virus. A coronavirus is a group of viruses, known to be zoonotic, causing illness ranging from acute to mild respiratory infections. These are spherical or pleomorphic enveloped particles containing positive sense RNA. The virus enters host cells, its uncoated genetic material transcribes, and translates. Since it has started spreading rapidly, protective measures have been taken all over the world. However, its transmission has been proved to be unstoppable and the absence of an effective drug makes the situation worse. The scientific community has gone all-out to discover and develop a possible vaccine or a competent antiviral drug. Other domains of biological sciences that promise effective results and target somewhat stable entities that are proteins, could be very useful in this time of crisis. Proteomics and metabolomics are the vast fields that are equipped with sufficient technologies to face this challenge. Various protein separation and identification techniques are available which facilitates the analysis of various types of interactions among proteins and their evolutionary lineages. The presented review aims at confronting the question: ‘how proteomics can help in tackling SARS-CoV-2?’ It deals with the role of upcoming proteome technology in these pandemic situations and discusses the proteomics approach towards the COVID-19 dilemma. Springer Singapore 2020-11-02 2020 /pmc/articles/PMC7605460/ /pubmed/33162722 http://dx.doi.org/10.1007/s42485-020-00052-9 Text en © Springer Nature Singapore Pte Ltd. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Rana, Rashmi
Rathi, Vaishnavi
Ganguly, Nirmal Kumar
A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies
title A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies
title_full A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies
title_fullStr A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies
title_full_unstemmed A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies
title_short A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies
title_sort comprehensive overview of proteomics approach for covid 19: new perspectives in target therapy strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605460/
https://www.ncbi.nlm.nih.gov/pubmed/33162722
http://dx.doi.org/10.1007/s42485-020-00052-9
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