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Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study

OBJECTIVE: To study longitudinal recovery trajectories of white matter after sports-related concussion (SRC) by performing diffusion tensor imaging (DTI) on collegiate athletes who sustained SRC. METHODS: Collegiate athletes (n = 219, 82 concussed athletes, 68 contact-sport controls, and 69 non–cont...

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Autores principales: Wu, Yu-Chien, Harezlak, Jaroslaw, Elsaid, Nahla M. H., Lin, Zikai, Wen, Qiuting, Mustafi, Sourajit M., Riggen, Larry D., Koch, Kevin M., Nencka, Andrew S., Meier, Timothy B., Mayer, Andrew R., Wang, Yang, Giza, Christopher C., DiFiori, John P., Guskiewicz, Kevin M., Mihalik, Jason P., LaConte, Stephen M., Duma, Stefan M., Broglio, Steven P., Saykin, Andrew J., McCrea, Michael A., McAllister, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605507/
https://www.ncbi.nlm.nih.gov/pubmed/32641518
http://dx.doi.org/10.1212/WNL.0000000000009930
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author Wu, Yu-Chien
Harezlak, Jaroslaw
Elsaid, Nahla M. H.
Lin, Zikai
Wen, Qiuting
Mustafi, Sourajit M.
Riggen, Larry D.
Koch, Kevin M.
Nencka, Andrew S.
Meier, Timothy B.
Mayer, Andrew R.
Wang, Yang
Giza, Christopher C.
DiFiori, John P.
Guskiewicz, Kevin M.
Mihalik, Jason P.
LaConte, Stephen M.
Duma, Stefan M.
Broglio, Steven P.
Saykin, Andrew J.
McCrea, Michael A.
McAllister, Thomas W.
author_facet Wu, Yu-Chien
Harezlak, Jaroslaw
Elsaid, Nahla M. H.
Lin, Zikai
Wen, Qiuting
Mustafi, Sourajit M.
Riggen, Larry D.
Koch, Kevin M.
Nencka, Andrew S.
Meier, Timothy B.
Mayer, Andrew R.
Wang, Yang
Giza, Christopher C.
DiFiori, John P.
Guskiewicz, Kevin M.
Mihalik, Jason P.
LaConte, Stephen M.
Duma, Stefan M.
Broglio, Steven P.
Saykin, Andrew J.
McCrea, Michael A.
McAllister, Thomas W.
author_sort Wu, Yu-Chien
collection PubMed
description OBJECTIVE: To study longitudinal recovery trajectories of white matter after sports-related concussion (SRC) by performing diffusion tensor imaging (DTI) on collegiate athletes who sustained SRC. METHODS: Collegiate athletes (n = 219, 82 concussed athletes, 68 contact-sport controls, and 69 non–contact-sport controls) were included from the Concussion Assessment, Research and Education Consortium. The participants completed clinical assessments and DTI at 4 time points: 24 to 48 hours after injury, asymptomatic state, 7 days after return-to-play, and 6 months after injury. Tract-based spatial statistics was used to investigate group differences in DTI metrics and to identify white-matter areas with persistent abnormalities. Generalized linear mixed models were used to study longitudinal changes and associations between outcome measures and DTI metrics. Cox proportional hazards model was used to study effects of white-matter abnormalities on recovery time. RESULTS: In the white matter of concussed athletes, DTI-derived mean diffusivity was significantly higher than in the controls at 24 to 48 hours after injury and beyond the point when the concussed athletes became asymptomatic. While the extent of affected white matter decreased over time, part of the corpus callosum had persistent group differences across all the time points. Furthermore, greater elevation of mean diffusivity at acute concussion was associated with worse clinical outcome measures (i.e., Brief Symptom Inventory scores and symptom severity scores) and prolonged recovery time. No significant differences in DTI metrics were observed between the contact-sport and non–contact-sport controls. CONCLUSIONS: Changes in white matter were evident after SRC at 6 months after injury but were not observed in contact-sport exposure. Furthermore, the persistent white-matter abnormalities were associated with clinical outcomes and delayed recovery time.
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spelling pubmed-76055072020-11-04 Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study Wu, Yu-Chien Harezlak, Jaroslaw Elsaid, Nahla M. H. Lin, Zikai Wen, Qiuting Mustafi, Sourajit M. Riggen, Larry D. Koch, Kevin M. Nencka, Andrew S. Meier, Timothy B. Mayer, Andrew R. Wang, Yang Giza, Christopher C. DiFiori, John P. Guskiewicz, Kevin M. Mihalik, Jason P. LaConte, Stephen M. Duma, Stefan M. Broglio, Steven P. Saykin, Andrew J. McCrea, Michael A. McAllister, Thomas W. Neurology Article OBJECTIVE: To study longitudinal recovery trajectories of white matter after sports-related concussion (SRC) by performing diffusion tensor imaging (DTI) on collegiate athletes who sustained SRC. METHODS: Collegiate athletes (n = 219, 82 concussed athletes, 68 contact-sport controls, and 69 non–contact-sport controls) were included from the Concussion Assessment, Research and Education Consortium. The participants completed clinical assessments and DTI at 4 time points: 24 to 48 hours after injury, asymptomatic state, 7 days after return-to-play, and 6 months after injury. Tract-based spatial statistics was used to investigate group differences in DTI metrics and to identify white-matter areas with persistent abnormalities. Generalized linear mixed models were used to study longitudinal changes and associations between outcome measures and DTI metrics. Cox proportional hazards model was used to study effects of white-matter abnormalities on recovery time. RESULTS: In the white matter of concussed athletes, DTI-derived mean diffusivity was significantly higher than in the controls at 24 to 48 hours after injury and beyond the point when the concussed athletes became asymptomatic. While the extent of affected white matter decreased over time, part of the corpus callosum had persistent group differences across all the time points. Furthermore, greater elevation of mean diffusivity at acute concussion was associated with worse clinical outcome measures (i.e., Brief Symptom Inventory scores and symptom severity scores) and prolonged recovery time. No significant differences in DTI metrics were observed between the contact-sport and non–contact-sport controls. CONCLUSIONS: Changes in white matter were evident after SRC at 6 months after injury but were not observed in contact-sport exposure. Furthermore, the persistent white-matter abnormalities were associated with clinical outcomes and delayed recovery time. Lippincott Williams & Wilkins 2020-08-18 /pmc/articles/PMC7605507/ /pubmed/32641518 http://dx.doi.org/10.1212/WNL.0000000000009930 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Wu, Yu-Chien
Harezlak, Jaroslaw
Elsaid, Nahla M. H.
Lin, Zikai
Wen, Qiuting
Mustafi, Sourajit M.
Riggen, Larry D.
Koch, Kevin M.
Nencka, Andrew S.
Meier, Timothy B.
Mayer, Andrew R.
Wang, Yang
Giza, Christopher C.
DiFiori, John P.
Guskiewicz, Kevin M.
Mihalik, Jason P.
LaConte, Stephen M.
Duma, Stefan M.
Broglio, Steven P.
Saykin, Andrew J.
McCrea, Michael A.
McAllister, Thomas W.
Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study
title Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study
title_full Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study
title_fullStr Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study
title_full_unstemmed Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study
title_short Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study
title_sort longitudinal white-matter abnormalities in sports-related concussion: a diffusion mri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605507/
https://www.ncbi.nlm.nih.gov/pubmed/32641518
http://dx.doi.org/10.1212/WNL.0000000000009930
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