Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with an increased risk of schizophrenia, obesity, Crohn’s disease, and reduced blood Mn. Here...

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Detalles Bibliográficos
Autores principales: Sunuwar, Laxmi, Frkatović, Azra, Sharapov, Sodbo, Wang, Qinchuan, Neu, Heather M., Wu, Xinqun, Haritunians, Talin, Wan, Fengyi, Michel, Sarah, Wu, Shaoguang, Donowitz, Mark, McGovern, Dermot, Lauc, Gordan, Sears, Cynthia, Melia, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605523/
https://www.ncbi.nlm.nih.gov/pubmed/32897876
http://dx.doi.org/10.1172/jci.insight.140978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605523/
https://www.ncbi.nlm.nih.gov/pubmed/32897876
http://dx.doi.org/10.1172/jci.insight.140978

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