Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Dilated cardiomyopathy (DCM) is often associated with sarcomere protein mutations that confer reduced myofilament tension–generating capacity. We demonstrated that cardiac twitch tension-time integrals can be targeted and tuned to prevent DCM remodeling in hearts with contractile dysfunction. We emp...

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Detalles Bibliográficos
Autores principales: Powers, Joseph D., Kooiker, Kristina B., Mason, Allison B., Teitgen, Abigail E., Flint, Galina V., Tardiff, Jil C., Schwartz, Steven D., McCulloch, Andrew D., Regnier, Michael, Davis, Jennifer, Moussavi-Harami, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605524/
https://www.ncbi.nlm.nih.gov/pubmed/32931484
http://dx.doi.org/10.1172/jci.insight.142446

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