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Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and potentially life-threatening impairment of vital organs. Despite the identification of causative genes, including NF2 (Merlin), INI1/SMARCB1, and LZTR1, the exact molecular mechanism of schwannoma development is still...

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Detalles Bibliográficos
Autores principales:	Chen, Zhiguo, Li, Stephen, Mo, Juan, Hawley, Eric, Wang, Yong, He, Yongzheng, Brosseau, Jean-Philippe, Shipman, Tracey, Clapp, D. Wade, Carroll, Thomas J., Le, Lu Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605536/ https://www.ncbi.nlm.nih.gov/pubmed/32960816 http://dx.doi.org/10.1172/jci.insight.141514

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