Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis

Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that are involved in a variety of human disorders, including cancer and autoimmune diseases. Although targeting PAD4 has shown no benefit in sepsis, the role of PAD2 remains unknown. Here, we report that PAD2 is engaged in...

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Detalles Bibliográficos
Autores principales: Tian, Yuzi, Qu, Shibin, Alam, Hasan B., Williams, Aaron M., Wu, Zhenyu, Deng, Qiufang, Pan, Baihong, Zhou, Jing, Liu, Baoling, Duan, Xiuzhen, Ma, Jianjie, Mondal, Santanu, Thompson, Paul R., Stringer, Kathleen A., Standiford, Theodore J., Li, Yongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605547/
https://www.ncbi.nlm.nih.gov/pubmed/33055424
http://dx.doi.org/10.1172/jci.insight.138873

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