A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

K777 is a di-peptide analog that contains an electrophilic vinyl-sulfone moiety and is a potent, covalent inactivator of cathepsins. Vero E6, HeLa/ACE2, Caco-2, A549/ACE2, and Calu-3, cells were exposed to SARS-CoV-2, and then treated with K777. K777 reduced viral infectivity with EC(50) values of i...

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Detalles Bibliográficos
Autores principales: Mellott, Drake M., Tseng, Chien-Te, Drelich, Aleksandra, Fajtová, Pavla, Chenna, Bala C., Kostomiris, Demetrios H., Hsu, Jason, Zhu, Jiyun, Taylor, Zane W., Tat, Vivian, Katzfuss, Ardala, Li, Linfeng, Giardini, Miriam A., Skinner, Danielle, Hirata, Ken, Beck, Sungjun, Carlin, Aaron F., Clark, Alex E., Beretta, Laura, Maneval, Daniel, Frueh, Felix, Hurst, Brett L., Wang, Hong, Kocurek, Klaudia I., Raushel, Frank M., O’Donoghue, Anthony J., de Siqueira-Neto, Jair Lage, Meek, Thomas D., McKerrow, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605553/
https://www.ncbi.nlm.nih.gov/pubmed/33140046
http://dx.doi.org/10.1101/2020.10.23.347534

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