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Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy

BACKGROUND: Alterations in the cell metabolism, such as enhanced aerobic glycolysis, have been identified as a prominent hallmark of cancer cells. 3-Bromopyruvate (3-BrPA) is a proverbial hexokinase (HK)-II inhibitor, which can inhibit cancer cell energy metabolism. Rapamycin is a new type macrocycl...

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Detalles Bibliográficos
Autores principales:	Gan, Lei, Ren, Yang, Lu, Jicheng, Ma, Junzhe, Shen, Xudong, Zhuang, Zhixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605667/ https://www.ncbi.nlm.nih.gov/pubmed/33149623 http://dx.doi.org/10.2147/OTT.S273108

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