A Potential Role of Interleukin 10 in COVID-19 Pathogenesis

A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL...

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Detalles Bibliográficos
Autores principales: Lu, Ligong, Zhang, Hui, Dauphars, Danielle J., He, You-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605819/
https://www.ncbi.nlm.nih.gov/pubmed/33214057
http://dx.doi.org/10.1016/j.it.2020.10.012
Descripción
Sumario:A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.

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