A Potential Role of Interleukin 10 in COVID-19 Pathogenesis

A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL...

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Detalles Bibliográficos
Autores principales: Lu, Ligong, Zhang, Hui, Dauphars, Danielle J., He, You-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605819/
https://www.ncbi.nlm.nih.gov/pubmed/33214057
http://dx.doi.org/10.1016/j.it.2020.10.012
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author Lu, Ligong
Zhang, Hui
Dauphars, Danielle J.
He, You-Wen
author_facet Lu, Ligong
Zhang, Hui
Dauphars, Danielle J.
He, You-Wen
author_sort Lu, Ligong
collection PubMed
description A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.
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spelling pubmed-76058192020-11-03 A Potential Role of Interleukin 10 in COVID-19 Pathogenesis Lu, Ligong Zhang, Hui Dauphars, Danielle J. He, You-Wen Trends Immunol Forum A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity. Elsevier Ltd. 2021-01 2020-11-02 /pmc/articles/PMC7605819/ /pubmed/33214057 http://dx.doi.org/10.1016/j.it.2020.10.012 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Lu, Ligong
Zhang, Hui
Dauphars, Danielle J.
He, You-Wen
A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
title A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
title_full A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
title_fullStr A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
title_full_unstemmed A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
title_short A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
title_sort potential role of interleukin 10 in covid-19 pathogenesis
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605819/
https://www.ncbi.nlm.nih.gov/pubmed/33214057
http://dx.doi.org/10.1016/j.it.2020.10.012
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