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Coagulation Disorders in COVID-19: Role of Toll-like Receptors

Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early respo...

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Autores principales: Biswas, Indranil, Khan, Gausal A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605922/
https://www.ncbi.nlm.nih.gov/pubmed/33149655
http://dx.doi.org/10.2147/JIR.S271768
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author Biswas, Indranil
Khan, Gausal A
author_facet Biswas, Indranil
Khan, Gausal A
author_sort Biswas, Indranil
collection PubMed
description Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation.
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spelling pubmed-76059222020-11-03 Coagulation Disorders in COVID-19: Role of Toll-like Receptors Biswas, Indranil Khan, Gausal A J Inflamm Res Review Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation. Dove 2020-10-29 /pmc/articles/PMC7605922/ /pubmed/33149655 http://dx.doi.org/10.2147/JIR.S271768 Text en © 2020 Biswas and Khan. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Biswas, Indranil
Khan, Gausal A
Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_full Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_fullStr Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_full_unstemmed Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_short Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_sort coagulation disorders in covid-19: role of toll-like receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605922/
https://www.ncbi.nlm.nih.gov/pubmed/33149655
http://dx.doi.org/10.2147/JIR.S271768
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