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GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer
BACKGROUND: Non‐small cell lung cancer (NSCLC) is the most common cause of cancer‐related death worldwide. The family of glutathione peroxidase (GPX), an important antioxidant enzyme in human tissues, has been discovered to play a key role in the development of cancers. GPX8 is the most promising mo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606007/ https://www.ncbi.nlm.nih.gov/pubmed/32975378 http://dx.doi.org/10.1111/1759-7714.13671 |
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author | Zhang, Jun Liu, Yun Guo, Yan Zhao, Qiang |
author_facet | Zhang, Jun Liu, Yun Guo, Yan Zhao, Qiang |
author_sort | Zhang, Jun |
collection | PubMed |
description | BACKGROUND: Non‐small cell lung cancer (NSCLC) is the most common cause of cancer‐related death worldwide. The family of glutathione peroxidase (GPX), an important antioxidant enzyme in human tissues, has been discovered to play a key role in the development of cancers. GPX8 is the most promising molecule of the family in a therapeutic strategy against a variety of cancers. The main purpose of this study was to examine and analyze the function and clinical value of GPX8 in NSCLC. METHODS: Immunohistochemistry (IHC), western blot analysis and quantitative real‐time polymerase chain reaction (qPCR) were used to assess GPX8 expression and its clinical significance in NSCLC. A series of cell biology experiments and bioinformatic analysis tools were further used to study the function of GPX8. RESULTS: GPX8 expression in tumor tissues was much higher than that in normal lung tissues. High expression of GPX8 in NSCLC was correlated with a worse clinical outcome and prognosis. Furthermore, GPX8 could inhibit the apoptosis of tumor cells and promote its migration and invasion. CONCLUSIONS: Our results conclusively demonstrated that GPX8 could affect the oncogenesis and prognosis of NSCLC via regulating epithelial characteristics. The study also illustrated that GPX8 could serve as a prognostic predictor and potential therapeutic target for NSCLC. |
format | Online Article Text |
id | pubmed-7606007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-76060072020-11-05 GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer Zhang, Jun Liu, Yun Guo, Yan Zhao, Qiang Thorac Cancer Original Articles BACKGROUND: Non‐small cell lung cancer (NSCLC) is the most common cause of cancer‐related death worldwide. The family of glutathione peroxidase (GPX), an important antioxidant enzyme in human tissues, has been discovered to play a key role in the development of cancers. GPX8 is the most promising molecule of the family in a therapeutic strategy against a variety of cancers. The main purpose of this study was to examine and analyze the function and clinical value of GPX8 in NSCLC. METHODS: Immunohistochemistry (IHC), western blot analysis and quantitative real‐time polymerase chain reaction (qPCR) were used to assess GPX8 expression and its clinical significance in NSCLC. A series of cell biology experiments and bioinformatic analysis tools were further used to study the function of GPX8. RESULTS: GPX8 expression in tumor tissues was much higher than that in normal lung tissues. High expression of GPX8 in NSCLC was correlated with a worse clinical outcome and prognosis. Furthermore, GPX8 could inhibit the apoptosis of tumor cells and promote its migration and invasion. CONCLUSIONS: Our results conclusively demonstrated that GPX8 could affect the oncogenesis and prognosis of NSCLC via regulating epithelial characteristics. The study also illustrated that GPX8 could serve as a prognostic predictor and potential therapeutic target for NSCLC. John Wiley & Sons Australia, Ltd 2020-09-25 2020-11 /pmc/articles/PMC7606007/ /pubmed/32975378 http://dx.doi.org/10.1111/1759-7714.13671 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Zhang, Jun Liu, Yun Guo, Yan Zhao, Qiang GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
title |
GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
title_full |
GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
title_fullStr |
GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
title_full_unstemmed |
GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
title_short |
GPX8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
title_sort | gpx8 promotes migration and invasion by regulating epithelial characteristics in non‐small cell lung cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606007/ https://www.ncbi.nlm.nih.gov/pubmed/32975378 http://dx.doi.org/10.1111/1759-7714.13671 |
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