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Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7

BACKGROUND: The E6 and E7 proteins in human papillomavirus 16 (HPV 16) are the main oncogenes in the occurrence of lung cancer. In recent studies, we found that E6 and E7 downregulated the expression of LKB1 in lung cancer cells. However, it is still unclear how E6 and E7 regulate LKB1 in lung cance...

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Detalles Bibliográficos
Autores principales: Hu, Yue, Wu, Ming‐Zhe, Gu, Na‐Jin, Xu, Hong‐Tao, Li, Qing‐Chang, Wu, Guang‐Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606012/
https://www.ncbi.nlm.nih.gov/pubmed/32945133
http://dx.doi.org/10.1111/1759-7714.13640