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Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports

BACKGROUND: Depression appears to be a common complication in patients during and post–COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a...

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Detalles Bibliográficos
Autores principales: Alpert, Orna, Begun, Leonid, Garren, Patrik, Solhkhah, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606074/
https://www.ncbi.nlm.nih.gov/pubmed/33163979
http://dx.doi.org/10.1016/j.bbih.2020.100173
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author Alpert, Orna
Begun, Leonid
Garren, Patrik
Solhkhah, Ramon
author_facet Alpert, Orna
Begun, Leonid
Garren, Patrik
Solhkhah, Ramon
author_sort Alpert, Orna
collection PubMed
description BACKGROUND: Depression appears to be a common complication in patients during and post–COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a new light on future treatment options for both disorders. OBJECTIVE: This review demonstrates the role of interleukins in COVID-19 pathogenesis and their role in depression. RESULTS: We described cases we have treated as an example for the dual role interleukins have in COVID-19 infection and depression and reviewed approximately 70 articles focusing on the role of interleukins in cytokine storm syndrome and depression. CONCLUSION: This review highlights the key features of cytokines in both diseases. As the scientific community has more time to recover and process the effect of the current pandemic, we believe that additional research will pave the way to diverse pathways to treat depression in these patient and others.
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spelling pubmed-76060742020-11-03 Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports Alpert, Orna Begun, Leonid Garren, Patrik Solhkhah, Ramon Brain Behav Immun Health Full Length Article BACKGROUND: Depression appears to be a common complication in patients during and post–COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a new light on future treatment options for both disorders. OBJECTIVE: This review demonstrates the role of interleukins in COVID-19 pathogenesis and their role in depression. RESULTS: We described cases we have treated as an example for the dual role interleukins have in COVID-19 infection and depression and reviewed approximately 70 articles focusing on the role of interleukins in cytokine storm syndrome and depression. CONCLUSION: This review highlights the key features of cytokines in both diseases. As the scientific community has more time to recover and process the effect of the current pandemic, we believe that additional research will pave the way to diverse pathways to treat depression in these patient and others. Elsevier 2020-11-03 /pmc/articles/PMC7606074/ /pubmed/33163979 http://dx.doi.org/10.1016/j.bbih.2020.100173 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Alpert, Orna
Begun, Leonid
Garren, Patrik
Solhkhah, Ramon
Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
title Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
title_full Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
title_fullStr Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
title_full_unstemmed Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
title_short Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports
title_sort cytokine storm induced new onset depression in patients with covid-19. a new look into the association between depression and cytokines -two case reports
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606074/
https://www.ncbi.nlm.nih.gov/pubmed/33163979
http://dx.doi.org/10.1016/j.bbih.2020.100173
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