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A catalogue of biochemically diverse CRISPR-Cas9 orthologs

Bacterial Cas9 nucleases from type II CRISPR-Cas antiviral defence systems have been repurposed as genome editing tools. Although these proteins are found in many microbes, only a handful of variants are used for these applications. Here, we use bioinformatic and biochemical analyses to explore this...

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Detalles Bibliográficos
Autores principales:	Gasiunas, Giedrius, Young, Joshua K., Karvelis, Tautvydas, Kazlauskas, Darius, Urbaitis, Tomas, Jasnauskaite, Monika, Grusyte, Mantvyda M., Paulraj, Sushmitha, Wang, Po-Hao, Hou, Zhenglin, Dooley, Shane K., Cigan, Mark, Alarcon, Clara, Chilcoat, N. Doane, Bigelyte, Greta, Curcuru, Jennifer L., Mabuchi, Megumu, Sun, Zhiyi, Fuchs, Ryan T., Schildkraut, Ezra, Weigele, Peter R., Jack, William E., Robb, G. Brett, Venclovas, Česlovas, Siksnys, Virginijus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606464/ https://www.ncbi.nlm.nih.gov/pubmed/33139742 http://dx.doi.org/10.1038/s41467-020-19344-1

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