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A unified framework for joint-tissue transcriptome-wide association and Mendelian Randomization analysis

Here we present a Joint-Tissue Imputation (JTI) approach and a Mendelian Randomization (MR) framework for causal inference, MR-JTI. JTI borrows information across transcriptomes of different tissues, leveraging shared genetic regulation, to improve prediction performance in a tissue-dependent manner...

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Detalles Bibliográficos
Autores principales:	Zhou, Dan, Jiang, Yi, Zhong, Xue, Cox, Nancy J., Liu, Chunyu, Gamazon, Eric R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606598/ https://www.ncbi.nlm.nih.gov/pubmed/33020666 http://dx.doi.org/10.1038/s41588-020-0706-2

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