Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays

The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-binding protein that plays important roles in tumorigenesis and adipogenesis. Previous results showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs by inhibiting its DNA-binding...

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Detalles Bibliográficos
Autores principales: Su, Linjia, Bryan, Nadezda, Battista, Sabrina, Freitas, Juliano, Garabedian, Alyssa, D’Alessio, Federica, Romano, Miriam, Falanga, Fabiana, Fusco, Alfredo, Kos, Lidia, Chambers, Jeremy, Fernandez-Lima, Francisco, Chapagain, Prem P., Vasile, Stefan, Smith, Layton, Leng, Fenfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606612/
https://www.ncbi.nlm.nih.gov/pubmed/33139812
http://dx.doi.org/10.1038/s41598-020-75890-0

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