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An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

The ability to directly measure acetylcholine (ACh) release is an essential step towards understanding its physiological function. Here, we optimized the GRAB(ACh) (GPCR-Activation‒Based-ACh) sensor to achieve substantially improved sensitivity in ACh detection, as well as reduced downstream couplin...

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Detalles Bibliográficos
Autores principales:	Jing, Miao, Li, Yuexuan, Zeng, Jianzhi, Huang, Pengcheng, Skirzewski, Miguel, Kljakic, Ornela, Peng, Wanling, Qian, Tongrui, Tan, Ke, Zou, Jing, Trinh, Simon, Wu, Runlong, Zhang, Shichen, Pan, Sunlei, Hires, Samuel A., Xu, Min, Li, Haohong, Saksida, Lisa M., Prado, Vania F., Bussey, Timothy J, Prado, Marco A.M., Chen, Liangyi, Cheng, Heping, Li, Yulong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606762/ https://www.ncbi.nlm.nih.gov/pubmed/32989318 http://dx.doi.org/10.1038/s41592-020-0953-2

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