Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Hydrogen sulfide (H(2)S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H(2)S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H(2)S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H(2)S in mitochondrial function and its effects on cellular physiology.