Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies

We describe a case of fulminant onset, rapidly progressive-interstitial lung disease (RP-ILD) with anti-ARS antibodies (anti-PL-7). The patient was successfully treated with nintedanib in addition to intensive immunosuppressive therapies, including intravenous cyclophosphamide. Nintedanib has just b...

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Autores principales: Yanagihara, Toyoshi, Suzuki, Kunihiro, Egashira, Ayaka, Ogo, Naruhiko, Asoh, Tatsuma, Nara, Tsukasa, Takatsuki, Kensaku, Yoshizawa, Seiji, Chong, Sy Giin, Hamada, Naoki, Maeyama, Takashige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606860/
https://www.ncbi.nlm.nih.gov/pubmed/33163354
http://dx.doi.org/10.1016/j.rmcr.2020.101272
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author Yanagihara, Toyoshi
Suzuki, Kunihiro
Egashira, Ayaka
Ogo, Naruhiko
Asoh, Tatsuma
Nara, Tsukasa
Takatsuki, Kensaku
Yoshizawa, Seiji
Chong, Sy Giin
Hamada, Naoki
Maeyama, Takashige
author_facet Yanagihara, Toyoshi
Suzuki, Kunihiro
Egashira, Ayaka
Ogo, Naruhiko
Asoh, Tatsuma
Nara, Tsukasa
Takatsuki, Kensaku
Yoshizawa, Seiji
Chong, Sy Giin
Hamada, Naoki
Maeyama, Takashige
author_sort Yanagihara, Toyoshi
collection PubMed
description We describe a case of fulminant onset, rapidly progressive-interstitial lung disease (RP-ILD) with anti-ARS antibodies (anti-PL-7). The patient was successfully treated with nintedanib in addition to intensive immunosuppressive therapies, including intravenous cyclophosphamide. Nintedanib has just been approved for treatment of progressive fibrosing ILD, but to date, no reports of RP-ILD treated with nintedanib have been published. This case report may advance discussions regarding the use and timing of nintedanib in treating RP-ILD.
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spelling pubmed-76068602020-11-06 Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies Yanagihara, Toyoshi Suzuki, Kunihiro Egashira, Ayaka Ogo, Naruhiko Asoh, Tatsuma Nara, Tsukasa Takatsuki, Kensaku Yoshizawa, Seiji Chong, Sy Giin Hamada, Naoki Maeyama, Takashige Respir Med Case Rep Case Report We describe a case of fulminant onset, rapidly progressive-interstitial lung disease (RP-ILD) with anti-ARS antibodies (anti-PL-7). The patient was successfully treated with nintedanib in addition to intensive immunosuppressive therapies, including intravenous cyclophosphamide. Nintedanib has just been approved for treatment of progressive fibrosing ILD, but to date, no reports of RP-ILD treated with nintedanib have been published. This case report may advance discussions regarding the use and timing of nintedanib in treating RP-ILD. Elsevier 2020-10-28 /pmc/articles/PMC7606860/ /pubmed/33163354 http://dx.doi.org/10.1016/j.rmcr.2020.101272 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yanagihara, Toyoshi
Suzuki, Kunihiro
Egashira, Ayaka
Ogo, Naruhiko
Asoh, Tatsuma
Nara, Tsukasa
Takatsuki, Kensaku
Yoshizawa, Seiji
Chong, Sy Giin
Hamada, Naoki
Maeyama, Takashige
Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies
title Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies
title_full Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies
title_fullStr Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies
title_full_unstemmed Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies
title_short Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies
title_sort nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ars antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606860/
https://www.ncbi.nlm.nih.gov/pubmed/33163354
http://dx.doi.org/10.1016/j.rmcr.2020.101272
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