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Mitochondrial Dysfunction and Kidney Stone Disease

Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaOx; the most common type), has been shown to be a...

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Detalles Bibliográficos
Autores principales: Chaiyarit, Sakdithep, Thongboonkerd, Visith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606861/
https://www.ncbi.nlm.nih.gov/pubmed/33192563
http://dx.doi.org/10.3389/fphys.2020.566506
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author Chaiyarit, Sakdithep
Thongboonkerd, Visith
author_facet Chaiyarit, Sakdithep
Thongboonkerd, Visith
author_sort Chaiyarit, Sakdithep
collection PubMed
description Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaOx; the most common type), has been shown to be associated with oxidative stress and tissue inflammation/injury. Recent evidence has demonstrated the involvement of mitochondrial dysfunction in CaOx crystal retention and aggregation as well as Randall’s plaque formation, all of which are the essential mechanisms for kidney stone formation. This review highlights the important roles of mitochondria in renal cell functions and provides the data obtained from previous investigations of mitochondria related to kidney stone disease. In addition, mechanisms for the involvement of mitochondrial dysfunction in the pathophysiology of kidney stone disease are summarized. Finally, future perspectives on the novel approach to prevent kidney stone formation by mitochondrial preservation are discussed.
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spelling pubmed-76068612020-11-13 Mitochondrial Dysfunction and Kidney Stone Disease Chaiyarit, Sakdithep Thongboonkerd, Visith Front Physiol Physiology Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaOx; the most common type), has been shown to be associated with oxidative stress and tissue inflammation/injury. Recent evidence has demonstrated the involvement of mitochondrial dysfunction in CaOx crystal retention and aggregation as well as Randall’s plaque formation, all of which are the essential mechanisms for kidney stone formation. This review highlights the important roles of mitochondria in renal cell functions and provides the data obtained from previous investigations of mitochondria related to kidney stone disease. In addition, mechanisms for the involvement of mitochondrial dysfunction in the pathophysiology of kidney stone disease are summarized. Finally, future perspectives on the novel approach to prevent kidney stone formation by mitochondrial preservation are discussed. Frontiers Media S.A. 2020-10-20 /pmc/articles/PMC7606861/ /pubmed/33192563 http://dx.doi.org/10.3389/fphys.2020.566506 Text en Copyright © 2020 Chaiyarit and Thongboonkerd. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Chaiyarit, Sakdithep
Thongboonkerd, Visith
Mitochondrial Dysfunction and Kidney Stone Disease
title Mitochondrial Dysfunction and Kidney Stone Disease
title_full Mitochondrial Dysfunction and Kidney Stone Disease
title_fullStr Mitochondrial Dysfunction and Kidney Stone Disease
title_full_unstemmed Mitochondrial Dysfunction and Kidney Stone Disease
title_short Mitochondrial Dysfunction and Kidney Stone Disease
title_sort mitochondrial dysfunction and kidney stone disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606861/
https://www.ncbi.nlm.nih.gov/pubmed/33192563
http://dx.doi.org/10.3389/fphys.2020.566506
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