Cargando…

PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment

BACKGROUND AND AIMS: Pyruvate kinase M2 (PKM2) is an essential regulator of the Warburg effect, but its biological function promoting immune escape of hepatocellular carcinoma (HCC) is unclear. METHODS: GEPIA web tool and immunohistochemistry (IHC) analysis were employed to evaluate the clinical rel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Tian-En, Wang, Shun, Shen, Xiao-Tian, Zhang, Ze, Chen, Mo, Wang, Hao, Zhu, Ying, Xu, Da, Hu, Bei-Yuan, Wei, Ran, Zheng, Yan, Dong, Qiong-Zhu, Qin, Lun-Xiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606949/ https://www.ncbi.nlm.nih.gov/pubmed/33193421 http://dx.doi.org/10.3389/fimmu.2020.589997

Ejemplares similares

Hypoxic Characteristic in the Immunosuppressive Microenvironment of Hepatocellular Carcinoma
por: Mo, Zhuomao, et al.
Publicado: (2021)

Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy
por: Rangel, Roberto, et al.
Publicado: (2022)

Overexpression of SMS in the tumor microenvironment is associated with immunosuppression in hepatocellular carcinoma
por: Xiang, Lin, et al.
Publicado: (2022)

The immunosuppressive microenvironment and immunotherapy in human glioblastoma
por: Zhang, Xuehua, et al.
Publicado: (2022)

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming
por: Zhang, Ze, et al.
Publicado: (2019)

Obesity contributes to hepatocellular carcinoma development via immunosuppressive microenvironment remodeling
por: Yang, Jian, et al.
Publicado: (2023)

Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma
por: Li, Ang, et al.
Publicado: (2023)

Cancer Stem Cells and Immunosuppressive Microenvironment in Glioma
por: Ma, Qianquan, et al.
Publicado: (2018)

The CXCL Family Contributes to Immunosuppressive Microenvironment in Gliomas and Assists in Gliomas Chemotherapy
por: Wang, Zeyu, et al.
Publicado: (2021)

Apoptosis, Pyroptosis, and Ferroptosis Conspiringly Induce Immunosuppressive Hepatocellular Carcinoma Microenvironment and γδ T-Cell Imbalance
por: Hu, Yi, et al.
Publicado: (2022)

Single-Cell Atlas Reveals Complexity of the Immunosuppressive Microenvironment of Initial and Recurrent Glioblastoma
por: Fu, Weilun, et al.
Publicado: (2020)

Advances in Hypofractionated Irradiation-Induced Immunosuppression of Tumor Microenvironment
por: Wang, Yuxia
Publicado: (2021)

Research progress on the role of PKM2 in the immune response
por: Liu, Chunyan, et al.
Publicado: (2022)

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma
por: DeCordova, Syreeta, et al.
Publicado: (2020)

Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma
por: Shi, Hong-Xiang, et al.
Publicado: (2022)

The m(6)A-related gene signature stratifies poor prognosis patients and characterizes immunosuppressive microenvironment in hepatocellular carcinoma
por: Ma, Ensi, et al.
Publicado: (2023)

An integrated overview of the immunosuppression features in the tumor microenvironment of pancreatic cancer
por: Guo, Jinglong, et al.
Publicado: (2023)

Prognosis and Dissection of Immunosuppressive Microenvironment in Breast Cancer Based on Fatty Acid Metabolism-Related Signature
por: Tang, Yuhui, et al.
Publicado: (2022)

Role of PKM2-Mediated Immunometabolic Reprogramming on Development of Cytokine Storm
por: Liu, Zhijun, et al.
Publicado: (2021)

Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma
por: Chen, Quan, et al.
Publicado: (2023)

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy
por: Li, Yiliang, et al.
Publicado: (2018)

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment
por: Cruz Cruz, Joselyn, et al.
Publicado: (2023)

Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
por: Huang, Boyuan, et al.
Publicado: (2023)

Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma
por: Chen, Chen, et al.
Publicado: (2023)

Transcriptome and single-cell analysis reveal the contribution of immunosuppressive microenvironment for promoting glioblastoma progression
por: Ni, Lulu, et al.
Publicado: (2023)

Deregulated bile acids may drive hepatocellular carcinoma metastasis by inducing an immunosuppressive microenvironment
por: Xia, Jin-kun, et al.
Publicado: (2022)

Prognosis stratification in breast cancer and characterization of immunosuppressive microenvironment through a pyrimidine metabolism-related signature
por: Luo, Yongzhou, et al.
Publicado: (2022)

Comprehensive Multi-Omics Identification of Interferon-γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

Molecular subtypes based on Wnt-signaling gene expression predict prognosis and tumor microenvironment in hepatocellular carcinoma
por: Xu, Weifeng, et al.
Publicado: (2022)

Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma
por: Lv, Junqiang, et al.
Publicado: (2022)

Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment
por: Sun, Hao-Ran, et al.
Publicado: (2019)

TANK shapes an immunosuppressive microenvironment and predicts prognosis and therapeutic response in glioma
por: Li, Shasha, et al.
Publicado: (2023)

Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy
por: Shafqat, Areez, et al.
Publicado: (2023)

Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas
por: Zhang, Po, et al.
Publicado: (2022)

Immunosuppressive Effect of B7-H4 Pathway in a Murine Systemic Lupus Erythematosus Model
por: Xiao, Ze Xiu, et al.
Publicado: (2017)

Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment
por: Wang, Weinan, et al.
Publicado: (2021)

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
por: Ruhland, Megan K., et al.
Publicado: (2016)

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
por: Monteran, Lea, et al.
Publicado: (2019)

FUCA2 Is a Prognostic Biomarker and Correlated With an Immunosuppressive Microenvironment in Pan-Cancer
por: Zhong, Anyuan, et al.
Publicado: (2021)

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment
por: Kaweme, Natasha Mupeta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9bhk5r5nfs8quqhc9ao978j0qu