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STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association

STARD1 moves cholesterol (CHOL) from the outer mitochondrial membrane (OMM) to the inner membrane (IMM) in steroidogenic cells. This activity is integrated into CHOL trafficking and synthesis homeostasis, involving uptake through SR-B1 and LDL receptors and distribution through endosomes, ER, and li...

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Detalles Bibliográficos
Autores principales: Larsen, Michele Campaigne, Lee, Jinwoo, Jorgensen, Joan S., Jefcoate, Colin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607000/
https://www.ncbi.nlm.nih.gov/pubmed/33193082
http://dx.doi.org/10.3389/fendo.2020.559674