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Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor

OBJECTIVE: To explore the effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. METHODS: Patients with malignant wounds who underwent dressing change at a wound outpatient clinic from September 2016 to February 2019 were randomized to an observati...

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Detalles Bibliográficos
Autores principales: Peng, Li, Dai, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607146/
https://www.ncbi.nlm.nih.gov/pubmed/31885300
http://dx.doi.org/10.1177/0300060519889746
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author Peng, Li
Dai, Yi
author_facet Peng, Li
Dai, Yi
author_sort Peng, Li
collection PubMed
description OBJECTIVE: To explore the effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. METHODS: Patients with malignant wounds who underwent dressing change at a wound outpatient clinic from September 2016 to February 2019 were randomized to an observation group (36 patients) or a control group (37 patients). The observation group was treated with metronidazole combined with debridement gel while the control group received wet dressing therapy combined with silver sulfadiazine. Malodor control was compared between the two groups from treatment initiation to days 3 and 12 after dressing change, and the social impact scale was used to compare stigma caused by malodor between the groups before and after treatment. RESULTS: The observation group had significantly superior malodor control on days 3 and 12 after dressing change compared with the control group. There was no difference in stigma between the two groups before treatment, but stigma in the observation group was significantly lower than that in the control group after treatment. CONCLUSION: Metronidazole combined with autolytic debridement can effectively reduce the malodor of cancerous wounds while controlling infection, and alleviate patient stigma caused by malodor.
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spelling pubmed-76071462020-11-12 Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor Peng, Li Dai, Yi J Int Med Res Prospective Clinical Research Report OBJECTIVE: To explore the effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. METHODS: Patients with malignant wounds who underwent dressing change at a wound outpatient clinic from September 2016 to February 2019 were randomized to an observation group (36 patients) or a control group (37 patients). The observation group was treated with metronidazole combined with debridement gel while the control group received wet dressing therapy combined with silver sulfadiazine. Malodor control was compared between the two groups from treatment initiation to days 3 and 12 after dressing change, and the social impact scale was used to compare stigma caused by malodor between the groups before and after treatment. RESULTS: The observation group had significantly superior malodor control on days 3 and 12 after dressing change compared with the control group. There was no difference in stigma between the two groups before treatment, but stigma in the observation group was significantly lower than that in the control group after treatment. CONCLUSION: Metronidazole combined with autolytic debridement can effectively reduce the malodor of cancerous wounds while controlling infection, and alleviate patient stigma caused by malodor. SAGE Publications 2019-12-29 /pmc/articles/PMC7607146/ /pubmed/31885300 http://dx.doi.org/10.1177/0300060519889746 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Peng, Li
Dai, Yi
Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
title Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
title_full Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
title_fullStr Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
title_full_unstemmed Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
title_short Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
title_sort effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607146/
https://www.ncbi.nlm.nih.gov/pubmed/31885300
http://dx.doi.org/10.1177/0300060519889746
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