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Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report

Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients...

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Autores principales: Gour-Provençal, Gabrielle, Newman, Nicholas M., Boudier-Revéret, Mathieu, Chang, Min Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607160/
https://www.ncbi.nlm.nih.gov/pubmed/33100075
http://dx.doi.org/10.1177/0300060520966896
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author Gour-Provençal, Gabrielle
Newman, Nicholas M.
Boudier-Revéret, Mathieu
Chang, Min Cheol
author_facet Gour-Provençal, Gabrielle
Newman, Nicholas M.
Boudier-Revéret, Mathieu
Chang, Min Cheol
author_sort Gour-Provençal, Gabrielle
collection PubMed
description Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients’ function. A 77-year-old man presented to our emergency department because of incapacitating pain and stiffness in the spine and hips. The patient had been diagnosed with biopsy-proven mycosis fungoides 3 years earlier and had been treated with oral acitretin at 25 to 50 mg daily since diagnosis. However, the patient gradually developed a severely limited range of motion in his spine and hips (left > right), significantly impairing his mobility and activities of daily living. Cervical and dorsolumbar radiographs showed extensive ossification along the anterior longitudinal ligament; this finding was compatible with DISH and had not been present in radiographs taken 3 years earlier. Pelvic radiographs showed multiple enthesophytes predominantly around the coxofemoral joints. DISH has been reported as a possible long-term adverse effect of acitretin. Despite optimal conservative treatment, the patient remained severely impaired and thus finally underwent extensive osteophyte excision and total hip replacement on the left side. His acitretin therapy was also stopped to prevent further progression of his DISH.
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spelling pubmed-76071602020-11-12 Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report Gour-Provençal, Gabrielle Newman, Nicholas M. Boudier-Revéret, Mathieu Chang, Min Cheol J Int Med Res Case Report Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients’ function. A 77-year-old man presented to our emergency department because of incapacitating pain and stiffness in the spine and hips. The patient had been diagnosed with biopsy-proven mycosis fungoides 3 years earlier and had been treated with oral acitretin at 25 to 50 mg daily since diagnosis. However, the patient gradually developed a severely limited range of motion in his spine and hips (left > right), significantly impairing his mobility and activities of daily living. Cervical and dorsolumbar radiographs showed extensive ossification along the anterior longitudinal ligament; this finding was compatible with DISH and had not been present in radiographs taken 3 years earlier. Pelvic radiographs showed multiple enthesophytes predominantly around the coxofemoral joints. DISH has been reported as a possible long-term adverse effect of acitretin. Despite optimal conservative treatment, the patient remained severely impaired and thus finally underwent extensive osteophyte excision and total hip replacement on the left side. His acitretin therapy was also stopped to prevent further progression of his DISH. SAGE Publications 2020-10-25 /pmc/articles/PMC7607160/ /pubmed/33100075 http://dx.doi.org/10.1177/0300060520966896 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Gour-Provençal, Gabrielle
Newman, Nicholas M.
Boudier-Revéret, Mathieu
Chang, Min Cheol
Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
title Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
title_full Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
title_fullStr Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
title_full_unstemmed Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
title_short Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
title_sort severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607160/
https://www.ncbi.nlm.nih.gov/pubmed/33100075
http://dx.doi.org/10.1177/0300060520966896
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