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Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report
Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607160/ https://www.ncbi.nlm.nih.gov/pubmed/33100075 http://dx.doi.org/10.1177/0300060520966896 |
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author | Gour-Provençal, Gabrielle Newman, Nicholas M. Boudier-Revéret, Mathieu Chang, Min Cheol |
author_facet | Gour-Provençal, Gabrielle Newman, Nicholas M. Boudier-Revéret, Mathieu Chang, Min Cheol |
author_sort | Gour-Provençal, Gabrielle |
collection | PubMed |
description | Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients’ function. A 77-year-old man presented to our emergency department because of incapacitating pain and stiffness in the spine and hips. The patient had been diagnosed with biopsy-proven mycosis fungoides 3 years earlier and had been treated with oral acitretin at 25 to 50 mg daily since diagnosis. However, the patient gradually developed a severely limited range of motion in his spine and hips (left > right), significantly impairing his mobility and activities of daily living. Cervical and dorsolumbar radiographs showed extensive ossification along the anterior longitudinal ligament; this finding was compatible with DISH and had not been present in radiographs taken 3 years earlier. Pelvic radiographs showed multiple enthesophytes predominantly around the coxofemoral joints. DISH has been reported as a possible long-term adverse effect of acitretin. Despite optimal conservative treatment, the patient remained severely impaired and thus finally underwent extensive osteophyte excision and total hip replacement on the left side. His acitretin therapy was also stopped to prevent further progression of his DISH. |
format | Online Article Text |
id | pubmed-7607160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-76071602020-11-12 Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report Gour-Provençal, Gabrielle Newman, Nicholas M. Boudier-Revéret, Mathieu Chang, Min Cheol J Int Med Res Case Report Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients’ function. A 77-year-old man presented to our emergency department because of incapacitating pain and stiffness in the spine and hips. The patient had been diagnosed with biopsy-proven mycosis fungoides 3 years earlier and had been treated with oral acitretin at 25 to 50 mg daily since diagnosis. However, the patient gradually developed a severely limited range of motion in his spine and hips (left > right), significantly impairing his mobility and activities of daily living. Cervical and dorsolumbar radiographs showed extensive ossification along the anterior longitudinal ligament; this finding was compatible with DISH and had not been present in radiographs taken 3 years earlier. Pelvic radiographs showed multiple enthesophytes predominantly around the coxofemoral joints. DISH has been reported as a possible long-term adverse effect of acitretin. Despite optimal conservative treatment, the patient remained severely impaired and thus finally underwent extensive osteophyte excision and total hip replacement on the left side. His acitretin therapy was also stopped to prevent further progression of his DISH. SAGE Publications 2020-10-25 /pmc/articles/PMC7607160/ /pubmed/33100075 http://dx.doi.org/10.1177/0300060520966896 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Gour-Provençal, Gabrielle Newman, Nicholas M. Boudier-Revéret, Mathieu Chang, Min Cheol Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report |
title | Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case
report |
title_full | Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case
report |
title_fullStr | Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case
report |
title_full_unstemmed | Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case
report |
title_short | Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case
report |
title_sort | severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case
report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607160/ https://www.ncbi.nlm.nih.gov/pubmed/33100075 http://dx.doi.org/10.1177/0300060520966896 |
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