AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

Liver metastasis is the main cause of colorectal cancer (CRC)‐related death. Neutrophil extracellular traps (NETs) play important roles in CRC progression. Deoxyribonuclease I (DNase I) has been shown to alter NET function by cleaving DNA strands comprising the NET backbone. Moreover, DNase I displa...

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Detalles Bibliográficos
Autores principales: Xia, Yujia, He, Jiayi, Zhang, Hongji, Wang, Han, Tetz, George, Maguire, Casey A., Wang, Yu, Onuma, Amblessed, Genkin, Dmitry, Tetz, Victor, Stepanov, Alexey, Terekhov, Stanislav, Ukrainskaya, Valeria, Huang, Hai, Tsung, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607180/
https://www.ncbi.nlm.nih.gov/pubmed/32813937
http://dx.doi.org/10.1002/1878-0261.12787

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