The CD14 gene –159C/T polymorphism and the risk of ischemic stroke: a meta-analysis

BACKGROUND: To investigate the association between the CD14 –159C/T polymorphism and ischemic stroke (IS). METHODS: Relevant literature was searched by retrieving EMBASE, Web of Science, Chinese National Knowledge Infrastructure, and PubMed databases. R version 3.33 software was applied to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Seven qualified studies with a total of 2058 IS patients and 2123 controls were included. There was no significant association between the CD14 –159C/T polymorphism and IS risk in the total population (TT vs CC: OR = 0.84, 95% CI = 0.58–1.20; CT vs CC: OR = 0.96, 95% CI = 0.82–1.12; dominant model: OR = 1.02, 95% CI = 0.80–1.30; recessive model: OR = 0.82, 95% CI = 0.57–1.19). Similarly, subgroup analysis according to ethnicity and Hardy–Weinberg equilibrium also found no significant interrelation. CONCLUSION: Our findings suggest that the CD14 –159C/T polymorphism does not contribute to the risk of IS. Well-designed studies with more subjects are required to further validate these results.