Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation

Nafamostat, a serine proteinase inhibitor with various actions including antithrombin, antiplasmin, and antitrypsin effects, has been used in clinical practice to treat disseminated intravascular coagulation (DIC) and pancreatitis. This case report describes the clinical course of a patient with COV...

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Autores principales: Takahashi, Wakana, Yoneda, Taro, Koba, Hayato, Ueda, Tsukasa, Tsuji, Noriaki, Ogawa, Haruhiko, Asakura, Hidesaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607231/
https://www.ncbi.nlm.nih.gov/pubmed/33157292
http://dx.doi.org/10.1016/j.ijid.2020.10.093
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author Takahashi, Wakana
Yoneda, Taro
Koba, Hayato
Ueda, Tsukasa
Tsuji, Noriaki
Ogawa, Haruhiko
Asakura, Hidesaku
author_facet Takahashi, Wakana
Yoneda, Taro
Koba, Hayato
Ueda, Tsukasa
Tsuji, Noriaki
Ogawa, Haruhiko
Asakura, Hidesaku
author_sort Takahashi, Wakana
collection PubMed
description Nafamostat, a serine proteinase inhibitor with various actions including antithrombin, antiplasmin, and antitrypsin effects, has been used in clinical practice to treat disseminated intravascular coagulation (DIC) and pancreatitis. This case report describes the clinical course of a patient with COVID-19 pneumonia whose severe hypoxemia, probably caused by DIC and pulmonary embolism, showed remarkable improvement with combination heparin and nafamostat therapy. In addition, beneficial mechanisms of nafamostat against COVID-19 and the necessity of attention to hyperkalemia as an adverse effect are discussed.
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spelling pubmed-76072312020-11-03 Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation Takahashi, Wakana Yoneda, Taro Koba, Hayato Ueda, Tsukasa Tsuji, Noriaki Ogawa, Haruhiko Asakura, Hidesaku Int J Infect Dis Case Report Nafamostat, a serine proteinase inhibitor with various actions including antithrombin, antiplasmin, and antitrypsin effects, has been used in clinical practice to treat disseminated intravascular coagulation (DIC) and pancreatitis. This case report describes the clinical course of a patient with COVID-19 pneumonia whose severe hypoxemia, probably caused by DIC and pulmonary embolism, showed remarkable improvement with combination heparin and nafamostat therapy. In addition, beneficial mechanisms of nafamostat against COVID-19 and the necessity of attention to hyperkalemia as an adverse effect are discussed. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-01 2020-11-03 /pmc/articles/PMC7607231/ /pubmed/33157292 http://dx.doi.org/10.1016/j.ijid.2020.10.093 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Takahashi, Wakana
Yoneda, Taro
Koba, Hayato
Ueda, Tsukasa
Tsuji, Noriaki
Ogawa, Haruhiko
Asakura, Hidesaku
Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation
title Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation
title_full Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation
title_fullStr Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation
title_full_unstemmed Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation
title_short Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation
title_sort potential mechanisms of nafamostat therapy for severe covid-19 pneumonia with disseminated intravascular coagulation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607231/
https://www.ncbi.nlm.nih.gov/pubmed/33157292
http://dx.doi.org/10.1016/j.ijid.2020.10.093
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