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Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value

BACKGROUND: Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Numerous studies have shown that long noncoding RNAs (lncRNAs) can affect the occurrence and development of cancer through a variety of signaling pathways. The...

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Autores principales: Yu, Xiuchong, Ding, Haixiang, Shi, Yijiu, Yang, Liangwei, Zhou, Jiaming, Yan, Zhilong, Xiao, Bingxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607276/
https://www.ncbi.nlm.nih.gov/pubmed/33163123
http://dx.doi.org/10.1155/2020/7347298
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author Yu, Xiuchong
Ding, Haixiang
Shi, Yijiu
Yang, Liangwei
Zhou, Jiaming
Yan, Zhilong
Xiao, Bingxiu
author_facet Yu, Xiuchong
Ding, Haixiang
Shi, Yijiu
Yang, Liangwei
Zhou, Jiaming
Yan, Zhilong
Xiao, Bingxiu
author_sort Yu, Xiuchong
collection PubMed
description BACKGROUND: Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Numerous studies have shown that long noncoding RNAs (lncRNAs) can affect the occurrence and development of cancer through a variety of signaling pathways. The abnormal expression and specificity of lncRNAs in tumors make them potential biomarkers of cancers. Nevertheless, the diagnostic roles of lncRNAs in GC have been poorly understood. So this study focuses on the clinical diagnostic value of lncRNAs in GC. MATERIALS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to investigate the expression of the linc-ROR (long intergenic noncoding RNA, regulator of reprogramming) in 105 paired GC tissues and adjacent normal tissues. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were established to assess the diagnostic value of linc-ROR. The relationship between expression of linc-ROR and clinicopathological factors of patients with GC was further explored. Kaplan-Meier analysis was performed to evaluate the prognostic value of linc-ROR expression. RESULTS: The linc-ROR expression level was significantly decreased in GC tissues compared with its adjacent nontumor tissues (n = 105, P < 0.001). We also discovered that linc-ROR was evidently downregulated in 68.6% (72/105) of GC tissues. The AUC's value of linc-ROR was up to 0.6495, with sensitivity and specificity of 0.7524 and 0.5143, respectively. Intriguingly, the linc-ROR expression levels were obviously associated with tumor differentiation (P = 0.004). Notably, the overall survival rate of GC patients with high expression of linc-ROR was significantly higher than those with low expression. CONCLUSION: Our data revealed that linc-ROR has clinical potential as a biomarker for the diagnosis of GC and assessment of its prognosis.
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spelling pubmed-76072762020-11-05 Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value Yu, Xiuchong Ding, Haixiang Shi, Yijiu Yang, Liangwei Zhou, Jiaming Yan, Zhilong Xiao, Bingxiu Dis Markers Research Article BACKGROUND: Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Numerous studies have shown that long noncoding RNAs (lncRNAs) can affect the occurrence and development of cancer through a variety of signaling pathways. The abnormal expression and specificity of lncRNAs in tumors make them potential biomarkers of cancers. Nevertheless, the diagnostic roles of lncRNAs in GC have been poorly understood. So this study focuses on the clinical diagnostic value of lncRNAs in GC. MATERIALS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to investigate the expression of the linc-ROR (long intergenic noncoding RNA, regulator of reprogramming) in 105 paired GC tissues and adjacent normal tissues. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were established to assess the diagnostic value of linc-ROR. The relationship between expression of linc-ROR and clinicopathological factors of patients with GC was further explored. Kaplan-Meier analysis was performed to evaluate the prognostic value of linc-ROR expression. RESULTS: The linc-ROR expression level was significantly decreased in GC tissues compared with its adjacent nontumor tissues (n = 105, P < 0.001). We also discovered that linc-ROR was evidently downregulated in 68.6% (72/105) of GC tissues. The AUC's value of linc-ROR was up to 0.6495, with sensitivity and specificity of 0.7524 and 0.5143, respectively. Intriguingly, the linc-ROR expression levels were obviously associated with tumor differentiation (P = 0.004). Notably, the overall survival rate of GC patients with high expression of linc-ROR was significantly higher than those with low expression. CONCLUSION: Our data revealed that linc-ROR has clinical potential as a biomarker for the diagnosis of GC and assessment of its prognosis. Hindawi 2020-10-24 /pmc/articles/PMC7607276/ /pubmed/33163123 http://dx.doi.org/10.1155/2020/7347298 Text en Copyright © 2020 Xiuchong Yu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Xiuchong
Ding, Haixiang
Shi, Yijiu
Yang, Liangwei
Zhou, Jiaming
Yan, Zhilong
Xiao, Bingxiu
Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value
title Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value
title_full Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value
title_fullStr Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value
title_full_unstemmed Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value
title_short Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value
title_sort downregulated expression of linc-ror in gastric cancer and its potential diagnostic and prognosis value
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607276/
https://www.ncbi.nlm.nih.gov/pubmed/33163123
http://dx.doi.org/10.1155/2020/7347298
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