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Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus

OBJECTIVE: To investigate the relationships among serum resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 120 patients with T2DM were divided into non-microangiopathy and microangiopathy groups. Sixty age- and sex-...

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Autores principales: Wang, Li-Kun, Wang, Hua, Wu, Xue-Liang, Shi, Li, Yang, Rui-Min, Wang, Yi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607287/
https://www.ncbi.nlm.nih.gov/pubmed/31891278
http://dx.doi.org/10.1177/0300060519870407
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author Wang, Li-Kun
Wang, Hua
Wu, Xue-Liang
Shi, Li
Yang, Rui-Min
Wang, Yi-Cheng
author_facet Wang, Li-Kun
Wang, Hua
Wu, Xue-Liang
Shi, Li
Yang, Rui-Min
Wang, Yi-Cheng
author_sort Wang, Li-Kun
collection PubMed
description OBJECTIVE: To investigate the relationships among serum resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 120 patients with T2DM were divided into non-microangiopathy and microangiopathy groups. Sixty age- and sex-matched healthy subjects were used as a normal control (NC) group. Body height, body mass, waist circumference, and blood pressure were determined, and waist/hip ratio (WHR), body mass index, blood glucose, lipids, resistin, leptin, adiponectin, free fatty acids (FFA), high-sensitivity C-reactive protein (hs-CRP), fasting insulin, hemoglobin A1c, and homeostatic model assessment of insulin resistance (HOMA-IR) were compared among the three groups. RESULTS: Serum levels of resistin, leptin, FFA, and hs-CRP were significantly higher and levels of adiponectin were significantly lower in patients in the non-microangiopathy (n = 60) and microangiopathy groups (n = 60) compared with the NC group (n = 60). Serum resistin and leptin levels in patients with T2DM were positively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but negatively correlated with high-density lipoprotein-cholesterol (HDL-C). Serum adiponectin levels in patients with T2DM were negatively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but positively correlated with HDL-C. CONCLUSION: Serum resistin, adiponectin, and leptin levels correlate with the occurrence of T2DM and microvascular complications.
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spelling pubmed-76072872020-11-13 Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus Wang, Li-Kun Wang, Hua Wu, Xue-Liang Shi, Li Yang, Rui-Min Wang, Yi-Cheng J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To investigate the relationships among serum resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 120 patients with T2DM were divided into non-microangiopathy and microangiopathy groups. Sixty age- and sex-matched healthy subjects were used as a normal control (NC) group. Body height, body mass, waist circumference, and blood pressure were determined, and waist/hip ratio (WHR), body mass index, blood glucose, lipids, resistin, leptin, adiponectin, free fatty acids (FFA), high-sensitivity C-reactive protein (hs-CRP), fasting insulin, hemoglobin A1c, and homeostatic model assessment of insulin resistance (HOMA-IR) were compared among the three groups. RESULTS: Serum levels of resistin, leptin, FFA, and hs-CRP were significantly higher and levels of adiponectin were significantly lower in patients in the non-microangiopathy (n = 60) and microangiopathy groups (n = 60) compared with the NC group (n = 60). Serum resistin and leptin levels in patients with T2DM were positively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but negatively correlated with high-density lipoprotein-cholesterol (HDL-C). Serum adiponectin levels in patients with T2DM were negatively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but positively correlated with HDL-C. CONCLUSION: Serum resistin, adiponectin, and leptin levels correlate with the occurrence of T2DM and microvascular complications. SAGE Publications 2019-12-31 /pmc/articles/PMC7607287/ /pubmed/31891278 http://dx.doi.org/10.1177/0300060519870407 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Wang, Li-Kun
Wang, Hua
Wu, Xue-Liang
Shi, Li
Yang, Rui-Min
Wang, Yi-Cheng
Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
title Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
title_full Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
title_fullStr Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
title_full_unstemmed Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
title_short Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
title_sort relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607287/
https://www.ncbi.nlm.nih.gov/pubmed/31891278
http://dx.doi.org/10.1177/0300060519870407
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