The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory Lineages

BACKGROUND & AIMS: Notch signaling maintains intestinal stem cells (ISCs). When ISCs exit the niche, Notch signaling among early progenitor cells at position +4/5 regulates their specification toward secretory vs enterocyte lineages (binary fate). The transcription factor ATOH1 is repressed by N...

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Detalles Bibliográficos
Autores principales: Baulies, Anna, Angelis, Nikolaos, Foglizzo, Valentina, Danielsen, E. Thomas, Patel, Harshil, Novellasdemunt, Laura, Kucharska, Anna, Carvalho, Joana, Nye, Emma, De Coppi, Paolo, Li, Vivian S.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607384/
https://www.ncbi.nlm.nih.gov/pubmed/32553763
http://dx.doi.org/10.1053/j.gastro.2020.06.012

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