IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

BACKGROUND & AIMS: Unregulated activity of interleukin (IL) 22 promotes intestinal tumorigenesis in mice. IL22 binds the antagonist IL22 subunit alpha 2 (IL22RA2, also called IL22BP). We studied whether alterations in IL22BP contribute to colorectal carcinogenesis in humans and mice. METHODS: We...

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Detalles Bibliográficos
Autores principales: Kempski, Jan, Giannou, Anastasios D., Riecken, Kristoffer, Zhao, Lilan, Steglich, Babett, Lücke, Jöran, Garcia-Perez, Laura, Karstens, Karl-Frederick, Wöstemeier, Anna, Nawrocki, Mikolaj, Pelczar, Penelope, Witkowski, Mario, Nilsson, Sven, Konczalla, Leonie, Shiri, Ahmad Mustafa, Kempska, Joanna, Wahib, Ramez, Brockmann, Leonie, Huber, Philipp, Gnirck, Ann-Christin, Turner, Jan-Eric, Zazara, Dimitra E., Arck, Petra C., Stein, Alexander, Simon, Ronald, Daubmann, Anne, Meiners, Jan, Perez, Daniel, Strowig, Till, Koni, Pandelakis, Kruglov, Andrey A., Sauter, Guido, Izbicki, Jakob R., Guse, Andreas H., Rösch, Thomas, Lohse, Ansgar W., Flavell, Richard A., Gagliani, Nicola, Huber, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607422/
https://www.ncbi.nlm.nih.gov/pubmed/32585307
http://dx.doi.org/10.1053/j.gastro.2020.06.033

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