c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates in cellular signaling in physiological and pathophysiological conditions. In th...

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Detalles Bibliográficos
Autores principales: Contreras, Pablo S., Tapia, Pablo J., González-Hódar, Lila, Peluso, Ivana, Soldati, Chiara, Napolitano, Gennaro, Matarese, Maria, Heras, Macarena Las, Valls, Cristian, Martinez, Alexis, Balboa, Elisa, Castro, Juan, Leal, Nancy, Platt, Frances M., Sobota, Andrzej, Winter, Dominic, Klein, Andrés D., Medina, Diego L., Ballabio, Andrea, Alvarez, Alejandra R., Zanlungo, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607485/
https://www.ncbi.nlm.nih.gov/pubmed/33163944
http://dx.doi.org/10.1016/j.isci.2020.101691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607485/
https://www.ncbi.nlm.nih.gov/pubmed/33163944
http://dx.doi.org/10.1016/j.isci.2020.101691

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