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PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

BACKGROUND: On-target off-tumor toxicity impedes the clinical application of chimeric antigen receptor-modified T cells (CAR-T cells) in the treatment of solid tumors. Previous reports proved that the combinatorial antigen recognition strategy could improve the safety profile of CAR-T cells by targe...

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Detalles Bibliográficos
Autores principales:	Liao, Qibin, Mao, Yunyu, He, Huan, Ding, Xiangqing, Zhang, Xiaoyan, Xu, Jianqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607631/ https://www.ncbi.nlm.nih.gov/pubmed/33292688 http://dx.doi.org/10.1186/s40364-020-00237-w

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