A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

BACKGROUND: Efforts to elucidate the function of enhancers in vivo are underway but their vast numbers alongside differing enhancer architectures make it difficult to determine their impact on gene activity. By systematically annotating multiple mouse tissues with super- and typical-enhancers, we ha...

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Detalles Bibliográficos
Autores principales: Sethi, Siddharth, Vorontsov, Ilya E., Kulakovskiy, Ivan V., Greenaway, Simon, Williams, John, Makeev, Vsevolod J., Brown, Steve D. M., Simon, Michelle M., Mallon, Ann-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607678/
https://www.ncbi.nlm.nih.gov/pubmed/33138777
http://dx.doi.org/10.1186/s12864-020-07109-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607678/
https://www.ncbi.nlm.nih.gov/pubmed/33138777
http://dx.doi.org/10.1186/s12864-020-07109-5

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