Dimethyl fumarate transfer into human milk

Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple sclerosis. It is unknown whether DMF or its primary metabolite monomethyl fumarate (MMF) are excreted into human milk. We present two cases of lactating patients who donated milk samples to study the transfer of MM...

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Autores principales: Ciplea, Andrea I., Datta, Palika, Rewers-Felkins, Kathleen, Baker, Teresa, Gold, Ralf, Hale, Thomas W., Hellwig, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Neurological Disorders in Women
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607748/
https://www.ncbi.nlm.nih.gov/pubmed/33193814
http://dx.doi.org/10.1177/1756286420968414
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author Ciplea, Andrea I.
Datta, Palika
Rewers-Felkins, Kathleen
Baker, Teresa
Gold, Ralf
Hale, Thomas W.
Hellwig, Kerstin
author_facet Ciplea, Andrea I.
Datta, Palika
Rewers-Felkins, Kathleen
Baker, Teresa
Gold, Ralf
Hale, Thomas W.
Hellwig, Kerstin
author_sort Ciplea, Andrea I.
collection PubMed
description Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple sclerosis. It is unknown whether DMF or its primary metabolite monomethyl fumarate (MMF) are excreted into human milk. We present two cases of lactating patients who donated milk samples to study the transfer of MMF into human milk following a week of 2 × 240 mg daily oral dose. Samples were analyzed using liquid chromatography mass spectrometry. The calculated relative infant dose was 0.019% and 0.007%. This is the first study to demonstrate that MMF is transferred into human milk, with only limited exposure to an infant.
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spelling pubmed-76077482020-11-13 Dimethyl fumarate transfer into human milk Ciplea, Andrea I. Datta, Palika Rewers-Felkins, Kathleen Baker, Teresa Gold, Ralf Hale, Thomas W. Hellwig, Kerstin Ther Adv Neurol Disord Neurological Disorders in Women Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple sclerosis. It is unknown whether DMF or its primary metabolite monomethyl fumarate (MMF) are excreted into human milk. We present two cases of lactating patients who donated milk samples to study the transfer of MMF into human milk following a week of 2 × 240 mg daily oral dose. Samples were analyzed using liquid chromatography mass spectrometry. The calculated relative infant dose was 0.019% and 0.007%. This is the first study to demonstrate that MMF is transferred into human milk, with only limited exposure to an infant. SAGE Publications 2020-10-31 /pmc/articles/PMC7607748/ /pubmed/33193814 http://dx.doi.org/10.1177/1756286420968414 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Neurological Disorders in Women
Ciplea, Andrea I.
Datta, Palika
Rewers-Felkins, Kathleen
Baker, Teresa
Gold, Ralf
Hale, Thomas W.
Hellwig, Kerstin
Dimethyl fumarate transfer into human milk
title Dimethyl fumarate transfer into human milk
title_full Dimethyl fumarate transfer into human milk
title_fullStr Dimethyl fumarate transfer into human milk
title_full_unstemmed Dimethyl fumarate transfer into human milk
title_short Dimethyl fumarate transfer into human milk
title_sort dimethyl fumarate transfer into human milk
topic Neurological Disorders in Women
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607748/
https://www.ncbi.nlm.nih.gov/pubmed/33193814
http://dx.doi.org/10.1177/1756286420968414
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