DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observed at particular regions of myeloma such as B cell-specific enhancers. The rece...

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Detalles Bibliográficos
Autores principales: Alberge, Jean-Baptiste, Magrangeas, Florence, Wagner, Mirko, Denié, Soline, Guérin-Charbonnel, Catherine, Campion, Loïc, Attal, Michel, Avet-Loiseau, Hervé, Carell, Thomas, Moreau, Philippe, Minvielle, Stéphane, Sérandour, Aurélien A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607866/
https://www.ncbi.nlm.nih.gov/pubmed/33138842
http://dx.doi.org/10.1186/s13148-020-00953-y

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