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Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study

BACKGROUND: Outcomes of chronic myeloid leukemia (CML) has been improved dramatically in the past two decades, but survival levels of CML patients varied in regions. Comprehensive epidemiological research is necessary to evaluate the global burden of CML. METHODS: All data used in our study came fro...

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Autores principales: Ning, Liqing, Hu, Chuanyu, Lu, Pingfan, Que, Yimei, Zhu, Xiaojian, Li, Dengju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607878/
https://www.ncbi.nlm.nih.gov/pubmed/33292593
http://dx.doi.org/10.1186/s40164-020-00185-z
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author Ning, Liqing
Hu, Chuanyu
Lu, Pingfan
Que, Yimei
Zhu, Xiaojian
Li, Dengju
author_facet Ning, Liqing
Hu, Chuanyu
Lu, Pingfan
Que, Yimei
Zhu, Xiaojian
Li, Dengju
author_sort Ning, Liqing
collection PubMed
description BACKGROUND: Outcomes of chronic myeloid leukemia (CML) has been improved dramatically in the past two decades, but survival levels of CML patients varied in regions. Comprehensive epidemiological research is necessary to evaluate the global burden of CML. METHODS: All data used in our study came from the Global Burden of Disease (GBD) study 2017. Incidence cases, death cases, disability-adjusted life-years (DALYs), and its corresponding age-standardized rate between 1990 to 2017 were used to describe the distribution of CML burden, according to age, sex, social-demographic index (SDI), and countries. Data about attributable risk factors contributing to CML deaths and DALYs were also extracted and analyzed. RESULTS: Globally, the disease burden of CML gradually decreased from 1990 to 2017. Higher SDI countries achieved a remarkable effect on diminishing the CML burden. Conversely, due to population growth, the incidence cases, death cases, and DALYs of CML in lower SDI quintiles showed an upward trend. India had the most incidence cases and death cases of CML in the world. Additionally, smoking was the most significant attributable risk factor contributing to CML deaths and DALYs, followed by high body mass index. CONCLUSION: The disease burden of CML decreased globally, especially in higher SDI countries in the past 28 years. The increasing incidence cases and death cases were mainly observed in lower SDI countries. Additionally, strategies to control modifiable risk factors such as smoking and high body mass index might be useful in diminishing mortality and DALYs.
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spelling pubmed-76078782020-11-03 Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study Ning, Liqing Hu, Chuanyu Lu, Pingfan Que, Yimei Zhu, Xiaojian Li, Dengju Exp Hematol Oncol Research BACKGROUND: Outcomes of chronic myeloid leukemia (CML) has been improved dramatically in the past two decades, but survival levels of CML patients varied in regions. Comprehensive epidemiological research is necessary to evaluate the global burden of CML. METHODS: All data used in our study came from the Global Burden of Disease (GBD) study 2017. Incidence cases, death cases, disability-adjusted life-years (DALYs), and its corresponding age-standardized rate between 1990 to 2017 were used to describe the distribution of CML burden, according to age, sex, social-demographic index (SDI), and countries. Data about attributable risk factors contributing to CML deaths and DALYs were also extracted and analyzed. RESULTS: Globally, the disease burden of CML gradually decreased from 1990 to 2017. Higher SDI countries achieved a remarkable effect on diminishing the CML burden. Conversely, due to population growth, the incidence cases, death cases, and DALYs of CML in lower SDI quintiles showed an upward trend. India had the most incidence cases and death cases of CML in the world. Additionally, smoking was the most significant attributable risk factor contributing to CML deaths and DALYs, followed by high body mass index. CONCLUSION: The disease burden of CML decreased globally, especially in higher SDI countries in the past 28 years. The increasing incidence cases and death cases were mainly observed in lower SDI countries. Additionally, strategies to control modifiable risk factors such as smoking and high body mass index might be useful in diminishing mortality and DALYs. BioMed Central 2020-11-03 /pmc/articles/PMC7607878/ /pubmed/33292593 http://dx.doi.org/10.1186/s40164-020-00185-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ning, Liqing
Hu, Chuanyu
Lu, Pingfan
Que, Yimei
Zhu, Xiaojian
Li, Dengju
Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
title Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
title_full Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
title_fullStr Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
title_full_unstemmed Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
title_short Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
title_sort trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607878/
https://www.ncbi.nlm.nih.gov/pubmed/33292593
http://dx.doi.org/10.1186/s40164-020-00185-z
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