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Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope

The ongoing global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is marked as one of the most challenging infectious diseases in the history of mankind with affliction of ~29,737,453 confirmed cases globally. Looking at the present scenario where there is a parallel increm...

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Autores principales: Kumar, Arun, Dey, Asmita Deka, Behl, Tapan, Chadha, Swati, Aggarwal, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608010/
https://www.ncbi.nlm.nih.gov/pubmed/33189613
http://dx.doi.org/10.1016/j.intimp.2020.107156
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author Kumar, Arun
Dey, Asmita Deka
Behl, Tapan
Chadha, Swati
Aggarwal, Vishal
author_facet Kumar, Arun
Dey, Asmita Deka
Behl, Tapan
Chadha, Swati
Aggarwal, Vishal
author_sort Kumar, Arun
collection PubMed
description The ongoing global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is marked as one of the most challenging infectious diseases in the history of mankind with affliction of ~29,737,453 confirmed cases globally. Looking at the present scenario where there is a parallel increment in curve with time, there is an utmost emergency to discover a perennial solution to this life-threatening virus which has led the Human race in an unusual state of affair. The entire health care fraternity is engaged in endeavouring an ultimate way out to hit this pandemic but no such research made till now has been approved yet, to have the potential to bring an end to this fatal situation. Although a few possible treatment choices exist at the moment yet the requirement to search for a still better therapeutic option remains persistent. Global laboratories are working day and night in search for an effective vaccine, many are undergoing clinical trials but their commercialization is no less than a year away. The present review highlights the current potential therapies viz., vaccines, immunotherapies, convulsant plasma therapies, corticosteroids, antithrombotic, intravenous immunoglobulins, nocturnal oxygen therapy etc. that may prove beneficial in attenuating the pandemic situation. However, comparison and presentation of collective data on the therapeutic advancements in mitigating the pandemic situation needs further clinical investigations in order to prove boon to mankind.
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spelling pubmed-76080102020-11-03 Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope Kumar, Arun Dey, Asmita Deka Behl, Tapan Chadha, Swati Aggarwal, Vishal Int Immunopharmacol Review The ongoing global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is marked as one of the most challenging infectious diseases in the history of mankind with affliction of ~29,737,453 confirmed cases globally. Looking at the present scenario where there is a parallel increment in curve with time, there is an utmost emergency to discover a perennial solution to this life-threatening virus which has led the Human race in an unusual state of affair. The entire health care fraternity is engaged in endeavouring an ultimate way out to hit this pandemic but no such research made till now has been approved yet, to have the potential to bring an end to this fatal situation. Although a few possible treatment choices exist at the moment yet the requirement to search for a still better therapeutic option remains persistent. Global laboratories are working day and night in search for an effective vaccine, many are undergoing clinical trials but their commercialization is no less than a year away. The present review highlights the current potential therapies viz., vaccines, immunotherapies, convulsant plasma therapies, corticosteroids, antithrombotic, intravenous immunoglobulins, nocturnal oxygen therapy etc. that may prove beneficial in attenuating the pandemic situation. However, comparison and presentation of collective data on the therapeutic advancements in mitigating the pandemic situation needs further clinical investigations in order to prove boon to mankind. Elsevier B.V. 2021-01 2020-11-03 /pmc/articles/PMC7608010/ /pubmed/33189613 http://dx.doi.org/10.1016/j.intimp.2020.107156 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Kumar, Arun
Dey, Asmita Deka
Behl, Tapan
Chadha, Swati
Aggarwal, Vishal
Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
title Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
title_full Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
title_fullStr Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
title_full_unstemmed Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
title_short Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
title_sort exploring the multifocal therapeutic approaches in covid-19: a ray of hope
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608010/
https://www.ncbi.nlm.nih.gov/pubmed/33189613
http://dx.doi.org/10.1016/j.intimp.2020.107156
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