Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-sp...

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Detalles Bibliográficos
Autores principales: Wei, Shuangshi, Duan, Shengbao, Liu, Xiaomei, Wang, Hongmei, Ding, Shaohua, Chen, Yezhou, Xie, Jinsong, Tian, Jingjing, Yu, Nong, Ge, pingju, Zhang, xinglin, chen, Xiaohong, Li, Yong, Meng, Qinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608017/
https://www.ncbi.nlm.nih.gov/pubmed/33191178
http://dx.doi.org/10.1016/j.intimp.2020.107172
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author Wei, Shuangshi
Duan, Shengbao
Liu, Xiaomei
Wang, Hongmei
Ding, Shaohua
Chen, Yezhou
Xie, Jinsong
Tian, Jingjing
Yu, Nong
Ge, pingju
Zhang, xinglin
chen, Xiaohong
Li, Yong
Meng, Qinglin
author_facet Wei, Shuangshi
Duan, Shengbao
Liu, Xiaomei
Wang, Hongmei
Ding, Shaohua
Chen, Yezhou
Xie, Jinsong
Tian, Jingjing
Yu, Nong
Ge, pingju
Zhang, xinglin
chen, Xiaohong
Li, Yong
Meng, Qinglin
author_sort Wei, Shuangshi
collection PubMed
description The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
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spelling pubmed-76080172020-11-03 Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2 Wei, Shuangshi Duan, Shengbao Liu, Xiaomei Wang, Hongmei Ding, Shaohua Chen, Yezhou Xie, Jinsong Tian, Jingjing Yu, Nong Ge, pingju Zhang, xinglin chen, Xiaohong Li, Yong Meng, Qinglin Int Immunopharmacol Short Communication The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19. Elsevier B.V. 2021-01 2020-11-03 /pmc/articles/PMC7608017/ /pubmed/33191178 http://dx.doi.org/10.1016/j.intimp.2020.107172 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Wei, Shuangshi
Duan, Shengbao
Liu, Xiaomei
Wang, Hongmei
Ding, Shaohua
Chen, Yezhou
Xie, Jinsong
Tian, Jingjing
Yu, Nong
Ge, pingju
Zhang, xinglin
chen, Xiaohong
Li, Yong
Meng, Qinglin
Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
title Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
title_full Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
title_fullStr Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
title_full_unstemmed Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
title_short Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
title_sort chicken egg yolk antibodies (igys) block the binding of multiple sars-cov-2 spike protein variants to human ace2
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608017/
https://www.ncbi.nlm.nih.gov/pubmed/33191178
http://dx.doi.org/10.1016/j.intimp.2020.107172
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