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Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?

Disseminated tuberculosis is a severe disease with high-mortality that requires early diagnosis and treatment. Intestinal tuberculosis accounts for only 2% of tuberculosis cases worldwide and is extremely rare in children. We report a case of a 4-year-old girl admitted due to disseminated tuberculos...

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Autores principales: Santos, Ana Carolina Etrusco Zaroni, Sztajnbok, Jaques, Duarte-Neto, Amaro Nunes, Sousa, Amanda Freire Tamburini, Lopes, Alessandra Geisler Daud, Barrientos, Anna Carlota Mott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608070/
https://www.ncbi.nlm.nih.gov/pubmed/33146307
http://dx.doi.org/10.1590/S1678-9946202062078
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author Santos, Ana Carolina Etrusco Zaroni
Sztajnbok, Jaques
Duarte-Neto, Amaro Nunes
Sousa, Amanda Freire Tamburini
Lopes, Alessandra Geisler Daud
Barrientos, Anna Carlota Mott
author_facet Santos, Ana Carolina Etrusco Zaroni
Sztajnbok, Jaques
Duarte-Neto, Amaro Nunes
Sousa, Amanda Freire Tamburini
Lopes, Alessandra Geisler Daud
Barrientos, Anna Carlota Mott
author_sort Santos, Ana Carolina Etrusco Zaroni
collection PubMed
description Disseminated tuberculosis is a severe disease with high-mortality that requires early diagnosis and treatment. Intestinal tuberculosis accounts for only 2% of tuberculosis cases worldwide and is extremely rare in children. We report a case of a 4-year-old girl admitted due to disseminated tuberculosis with extensive intestinal involvement characterized by massive intestinal bleeding and hemorrhagic shock. The severity of the intestinal involvement precluded the exclusive use of oral anti-tuberculosis drugs and the patient was successfully treated with a combination of injectable and oral anti-tuberculosis agents. We discuss the importance of a regimen with injectable drugs for treating severe forms of tuberculosis in which the intestinal involvement impaired the use of oral drugs.
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spelling pubmed-76080702020-11-13 Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use? Santos, Ana Carolina Etrusco Zaroni Sztajnbok, Jaques Duarte-Neto, Amaro Nunes Sousa, Amanda Freire Tamburini Lopes, Alessandra Geisler Daud Barrientos, Anna Carlota Mott Rev Inst Med Trop Sao Paulo Case Report Disseminated tuberculosis is a severe disease with high-mortality that requires early diagnosis and treatment. Intestinal tuberculosis accounts for only 2% of tuberculosis cases worldwide and is extremely rare in children. We report a case of a 4-year-old girl admitted due to disseminated tuberculosis with extensive intestinal involvement characterized by massive intestinal bleeding and hemorrhagic shock. The severity of the intestinal involvement precluded the exclusive use of oral anti-tuberculosis drugs and the patient was successfully treated with a combination of injectable and oral anti-tuberculosis agents. We discuss the importance of a regimen with injectable drugs for treating severe forms of tuberculosis in which the intestinal involvement impaired the use of oral drugs. Instituto de Medicina Tropical 2020-10-30 /pmc/articles/PMC7608070/ /pubmed/33146307 http://dx.doi.org/10.1590/S1678-9946202062078 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Santos, Ana Carolina Etrusco Zaroni
Sztajnbok, Jaques
Duarte-Neto, Amaro Nunes
Sousa, Amanda Freire Tamburini
Lopes, Alessandra Geisler Daud
Barrientos, Anna Carlota Mott
Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
title Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
title_full Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
title_fullStr Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
title_full_unstemmed Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
title_short Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
title_sort severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608070/
https://www.ncbi.nlm.nih.gov/pubmed/33146307
http://dx.doi.org/10.1590/S1678-9946202062078
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